# Antiarthritic and Antinociceptive Properties of Ylang-Ylang (Cananga odorata) Essential Oil in Experimental Models

## TL;DR

This study shows that ylang-ylang essential oil reduces inflammation and pain in mice models of arthritis and persistent inflammation.

## Contribution

The study demonstrates the antiarthritic, anti-hyperalgesic, and antinociceptive effects of ylang-ylang essential oil in experimental models.

## Key findings

- YEO treatment reduced leukocyte infiltration and joint edema in zymosan-induced arthritis.
- YEO reduced mechanical hyperalgesia and interleukin-6 levels in arthritis and persistent inflammation models.
- YEO exhibited antinociceptive effects in acetic acid and formalin-induced pain models.

## Abstract

The aim of this study was to evaluate the effect of ylang-ylang (Cananga odorata) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted to zymosan-induced arthritis 6 h and 7 days after arthritis induction. At these doses, YEO treatment reduced the formation of joint edema 4 and 6 h after arthritis induction, and at a dose of 200 mg/kg, YEO treatment reduced mechanical hyperalgesia 3 and 4 h after arthritis induction. At the dose of 200 mg/kg, YEO treatment reduced interleukin-6 (IL-6) levels and cartilage destruction in the zymosan-induced arthritis model, and reduced edema formation and mechanical hyperalgesia in the model of persistent inflammation (21 days) induced by complete Freund’s adjuvant (CFA) in mice. YEO treatment at a dose of 200 mg/kg reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. The YEO treatment reduced inflammatory parameters in the experimental arthritis model, and presented antiarthritic, anti-hyperalgesic, antinociceptive, and anti-inflammatory properties.