# Ceruloplasmin and Lipofuscin Serum Concentrations Are Associated with Presence of Hypertrophic Cardiomyopathy

## TL;DR

This study found that higher levels of ceruloplasmin and lipofuscin in blood are linked to hypertrophic cardiomyopathy, suggesting potential biomarkers for detection.

## Contribution

The study identifies ceruloplasmin and lipofuscin as novel oxidative stress markers with diagnostic potential for hypertrophic cardiomyopathy.

## Key findings

- HCM patients had significantly higher ceruloplasmin and lipofuscin levels compared to controls.
- Ceruloplasmin showed strong discriminatory power (AUC 0.924) for HCM detection.
- Superoxide dismutase had limited utility for HCM detection (AUC 0.556).

## Abstract

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and cells’ ability to neutralize them by antioxidant systems. The role of oxidative stress in hypertrophic cardiomyopathy (HCM) is not fully understood. The aim of the study was to examine selected parameters of oxidative stress in patients with HCM compared to the control group. We enrolled 85 consecutive HCM patients and 97 controls without HCM. The groups were matched for sex, the body mass index, and age. Oxidative stress markers included superoxide dismutase (SOD), ceruloplasmin (CER), and lipofuscin (LPS). The median age of the HCM patients was 53 (40–63) years, and 41.2% of them were male. HCM patients, compared to the control ones, had significantly increased levels of CER and LPS. The areas under the receiver operating characteristics curves (AUC) indicated a good discriminatory power of CER (AUC 0.924, sensitivity 84%, and specificity 88%), an acceptable discriminatory power of LPS (AUC 0.740, sensitivity 66%, and specificity 72%), and poor discriminatory power of SOD (AUC 0.556, sensitivity 34%, and specificity 94%) for HCM detection. CER with good predictive strength, as well as LPS with acceptable predictive power, allows for HCM detection. The utility of SOD for HCM detection is limited.