# Transcriptomic Signatures in Lung Allografts and Their Therapeutic Implications

## TL;DR

This review explores how combining lung preservation with gene expression analysis can improve donor lung function and develop targeted therapies.

## Contribution

The paper reviews the integration of transcriptomics with EVLP to guide therapeutic strategies for lung allografts.

## Key findings

- Transcriptomic analysis reveals molecular pathways in lung allografts during preservation.
- Combining EVLP with gene expression data can lead to targeted therapies for donor lungs.
- Current therapeutics are being optimized using transcriptional insights for better lung function.

## Abstract

Ex vivo lung perfusion (EVLP) is a well-established method of lung preservation in clinical transplantation. Transcriptomic analyses of cells and tissues uncover gene expression patterns which reveal granular molecular pathways and cellular programs under various conditions. Coupling EVLP and transcriptomics may provide insights into lung allograft physiology at a molecular level with the potential to develop targeted therapies to enhance or repair the donor lung. This review examines the current landscape of transcriptional analysis of lung allografts in the context of state-of-the-art therapeutics that have been developed to optimize lung allograft function.