# Bilateral Infiltrating Ductal Carcinoma With Adrenal Metastasis: A Rare Case Report

**Authors:** Pragna Puvvada, Dakshayani S Nirhale, Romi H Gaudani, Praveen Mane

PMC · DOI: 10.7759/cureus.65635 · Cureus · 2024-07-29

## TL;DR

A rare case of bilateral breast cancer spreading to the adrenal gland is reported, emphasizing the need for early diagnosis and better treatment protocols.

## Contribution

This case report highlights the rare occurrence of adrenal metastasis from infiltrating ductal carcinoma, contributing to limited clinical data on this condition.

## Key findings

- A 43-year-old female presented with bilateral infiltrating ductal carcinoma and adrenal metastasis.
- The patient had positive ER and PR status but negative HER2 status.
- Adrenalectomy is planned after chemotherapy to manage the metastasis.

## Abstract

Adrenal gland metastasis is rare, often associated with invasive lobular carcinoma (ILC) rather than infiltrating ductal carcinoma (IDC). This report presents a case of a 43-year-old female with bilateral breast IDC and metastasis to the adrenal gland, with bilateral axillary and supraclavicular node involvement. Initial symptoms included a nipple discharge and a palpable lump. Diagnostic imaging and biopsy confirmed IDC, grade 2, with positive estrogen receptor (ER) and progesterone receptor (PR) status and negative human epidermal growth factor receptor 2 (HER2) status. The patient is undergoing chemotherapy and radiotherapy, with adrenalectomy planned post chemotherapy. The case underscores the need for early diagnosis and rapid treatment to improve outcomes, highlighting the paucity of data on managing solitary adrenal metastasis from IDC. Further research and clinical trials are essential to develop standardized treatment protocols.

## Linked entities

- **Proteins:** EREG (epiregulin), PGR (progesterone receptor), ERBB2 (erb-b2 receptor tyrosine kinase 2)
- **Diseases:** infiltrating ductal carcinoma (MONDO:0004953), breast cancer (MONDO:0004989)

## Full-text entities

- **Genes:** PGR (progesterone receptor) [NCBI Gene 5241] {aka NR3C3, PR}, ESR1 (estrogen receptor 1) [NCBI Gene 2099] {aka ER, ESR, ESRA, ESTRR, Era, NR3A1}
- **Diseases:** nipple discharge (MESH:C000626393), ILC (MESH:D018275), IDC (MESH:D044584), lump (MESH:C536531), Adrenal Metastasis (MESH:D009362), Adrenal gland metastasis (MESH:D000307)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11350619/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC11350619/full.md

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Source: https://tomesphere.com/paper/PMC11350619