# Current Approaches to Prevent or Reverse Microbiome Dysbiosis in Chronic Inflammatory Rheumatic Diseases

## TL;DR

This paper reviews current strategies to prevent or reverse microbiome imbalances in chronic inflammatory rheumatic diseases, aiming to improve patient outcomes.

## Contribution

The paper provides a comprehensive review of approaches to address microbiome dysbiosis in chronic inflammatory rheumatic diseases.

## Key findings

- Microbiome dysbiosis is linked to the pathogenesis and clinical outcomes of chronic inflammatory rheumatic diseases.
- Current strategies aim to prevent or reverse microbiome imbalances to improve therapeutic responses in patients.
- The review offers practical insights for healthcare professionals managing these conditions.

## Abstract

Advances in knowledge of the microbiome and its relationship with the immune system have led to a better understanding of the pathogenesis of chronic inflammatory rheumatic diseases (CIRD). Indeed, the microbiome dysbiosis now occupies a particular place with implications for the determinism and clinical expression of CIRD, as well as the therapeutic response of affected patients. Several approaches exist to limit the impact of the microbiome during CIRD. This review aimed to present current strategies to prevent or reverse microbiome dysbiosis based on existing knowledge, in order to provide practical information to healthcare professionals treating patients suffering from CIRD.