# Influence of the leukoreduction moment of blood components on the clinical outcomes of transfused patients in the emergency department

## TL;DR

This study found that blood components reduced for white blood cells before storage led to shorter hospital stays for emergency patients.

## Contribution

The study identifies the timing of leukoreduction as a factor affecting hospital stay duration in emergency transfusions.

## Key findings

- Pre-storage leukoreduction was associated with shorter hospital stays.
- Leukoreduction timing did not affect transfusion reactions, infections, or mortality.
- The effect was consistent across red blood cells and platelet transfusions.

## Abstract

to investigate the influence of the leukoreduction moment (preor post-storage) of blood components on the clinical outcomes of patients transfused in the emergency department.

retrospective cohort study of patients aged 18 years or older who received preor post-storage leukoreduced red blood cell or platelet concentrate in the emergency department and remained in the institution for more than 24 hours. A generalized mixed-effects model was applied in the analyses.

in a sample of 373 patients (63.27% male, mean age 54.83) and 643 transfusions (69.98% red blood cell), it was identified that the leukoreduction moment influenced the length of hospital stay (p<0.009), but was not dependent on the transfused blood component (p=0.124). The leukoreduction moment had no effect (p>0.050) on transfusion reactions, healthcare-associated infections, or mortality.

patients who received pre-storage leukoreduced blood components in the emergency department had a shorter length of hospital stay.

verificar a influência do momento da leucorredução (pré ou pós-armazenamento) de hemocomponentes na evolução clínica de pacientes transfundidos na emergência.

coorte retrospectiva de pacientes com idade igual ou maior de 18 anos que receberam, no departamento de emergência, concentrado de hemácias ou plaquetas leucorreduzidas pré ou pós-armazenamento. Modelo de efeitos mistos generalizado foi aplicado nas análises.

na amostra de 373 pacientes (63,27% homens, idade média 54,83) e 643 transfusões (69,98% concentrado de hemácias) foi identificado que o momento da leucorredução influenciou o tempo de internação hospitalar dos pacientes (p<0,009), porém não foi dependente do hemocomponente transfundido (p=0,124). O momento da leucorredução não teve efeito (p>0,050) nas variáveis reação transfusional, infecção relacionada à assistência à saúde e óbito.

pacientes que receberam na emergência hemocomponente leucorreduzido pré-armazenamento apresentaram menor tempo de internação hospitalar.