# Late-Onset Angioedema With Olanzapine in a Tertiary Hospital

## TL;DR

This paper reviews the rare but serious side effect of angioedema caused by the antipsychotic drug olanzapine and discusses its mechanisms and clinical implications.

## Contribution

The paper provides a comprehensive review of olanzapine-induced angioedema, focusing on mechanisms and clinical management.

## Key findings

- Olanzapine is associated with a rare but potentially life-threatening side effect of angioedema.
- Immunological or idiosyncratic reactions are suspected to be involved in the mechanism of olanzapine-induced angioedema.
- The paper discusses risk factors, diagnosis, and treatment options for this condition.

## Abstract

A medical condition known as angioedema is characterized by sudden swelling of the mucosa, subcutaneous tissue, dermis, and submucosal tissues. If airway obstruction results in respiratory distress, this condition may be fatal. Histamine, bradykinin, and leukotrienes are just a few of the complex chemotactic mediators that play a role in the pathophysiology of angioedema and can lead to fluid buildup in deeper skin layers. Many things, such as medication side effects, genetic disorders, and allergic reactions, can cause angioedema.
Olanzapine, an atypical antipsychotic mainly used to treat a few mental disorders, is one notable drug linked to angioedema. Angioedema is a documented side effect of olanzapine, albeit rare. Although the exact mechanism by which olanzapine causes angioedema is unknown, immunological-mediated or idiosyncratic reactions are thought to be involved. This study aims to review the current literature on the association between olanzapine and angioedema, including potential mechanisms of action and implications for clinical management. The possible risk factors, presentation, diagnosis, and treatment options for olanzapine-induced angioedema will also be discussed.