# 7-Methylguanine Inhibits Colon Cancer Growth in Vivo

## TL;DR

7-Methylguanine (7-MG) was found to inhibit colon cancer growth in mice by penetrating tumor tissue and suppressing tumor development.

## Contribution

The study demonstrates the in vivo efficacy of 7-MG in suppressing colon cancer in two distinct mouse models.

## Key findings

- 7-MG effectively penetrates tumor tissue in mice.
- 7-MG suppresses colon adenocarcinoma growth in the Akatol mouse model.
- 7-MG inhibits tumor growth in a xenograft model with human HCT116 cells.

## Abstract

7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1
and tRNA-guanine transglycosylase, the enzymatic activity of which is central
for the proliferation of cancer cells. Recently, a number of preclinical tests
have demonstrated the safety of 7-MG and a regimen of intragastric
administration was established in mice. In the present work, the
pharmacological activity of 7-MG was studied in BALB/c and BALB/c nude mice
with transplanted tumors. It was found that 7-MG effectively penetrates tumor
tissue and suppresses colon adenocarcinoma growth in the Akatol model, as well
as in a xenograft model with human HCT116 cells.