# Oculogyric Crisis Following Dosage Increase of Aripiprazole: A Case Report

## TL;DR

A 24-year-old man developed oculogyric crisis after increasing aripiprazole dosage, which was successfully treated with benztropine and diphenhydramine.

## Contribution

This case report documents aripiprazole-induced oculogyric crisis and its effective management with benztropine and diphenhydramine.

## Key findings

- Aripiprazole dosage increase led to oculogyric crisis in a psychiatric patient.
- Benztropine and diphenhydramine resolved the crisis promptly.
- The case highlights the need for monitoring for dystonic side effects with aripiprazole.

## Abstract

Oculogyric crisis (OGC) is a form of acute dystonia with involuntary conjugated ocular gaze in a fixed position. Common causes include metabolic disorders and medications, primarily typical antipsychotics. A 24-year-old male with a history of persistent depressive disorder and possible bipolar disorder was admitted to the psychiatric unit due to suicidal ideation. He was started on aripiprazole 5 mg and subsequently increased to 10 mg due to uncontrolled mood disorder. The patient subsequently developed OGC, which resolved with benztropine and diphenhydramine. This case report highlights aripiprazole-induced OGC and prompt management with benztropine and first-generation antihistamines.