# Genome-wide association study on meningioma risk in Japan: a multicenter prospective study

## TL;DR

This study is the first genome-wide association study of meningioma in Japan and found no significant genetic variants linked to the condition in the Japanese population.

## Contribution

The first genome-wide association study of meningioma in an East Asian population, providing a baseline for future research.

## Key findings

- No genome-wide significant SNPs were identified in the Japanese population.
- Previously reported risk variants rs11012732 and rs2686876 showed no significant association due to low minor allele frequency in the Japanese population.

## Abstract

Although meningiomas are the most common primary intracranial tumors, their genetic etiologies have not been fully elucidated. To date, only two genome-wide association studies (GWASs) have focused on European ancestries, despite ethnic differences in the incidence of meningiomas. The aim of this study was to conduct the first GWAS of Japanese patients with meningiomas to identify the SNPs associated with meningioma susceptibility.

In this multicenter prospective case-control study, we studied 401 Japanese patients with meningioma admitted in five institutions in Japan, and 50,876 control participants of Japanese ancestry enrolled in Biobank Japan.

The quality control process yielded 536,319 variants and imputation resulted in 8,224,735 variants on the autosomes and 224,820 variants on the X chromosomes. This GWAS eventually revealed no genetic variants with genome-wide significance (P < 5 × 10 − 8) and observed no significant association in the previously reported risk variants rs11012732 and rs2686876 due to low minor allele frequency in the Japanese population.

This is the first GWAS of meningiomas in East Asian populations and is expected to contribute to the development of GWAS research for meningiomas.

The online version contains supplementary material available at 10.1007/s11060-024-04727-x.