# Leiomyosarcoma of the Duodenum: A Case Report on a Rarely Encountered Tumor

## TL;DR

This case report describes a rare leiomyosarcoma in the duodenum of an 82-year-old woman, emphasizing diagnostic challenges and the need for interdisciplinary care.

## Contribution

The novelty lies in documenting a rare case of duodenal leiomyosarcoma and highlighting its clinical and diagnostic complexities.

## Key findings

- An 82-year-old female was diagnosed with duodenal leiomyosarcoma via biopsy and immunohistochemistry.
- Duodenal LMS presents with nonspecific symptoms and diagnostic challenges, requiring interdisciplinary collaboration.
- The case underscores the importance of tailored therapeutic strategies for rare tumors like duodenal LMS.

## Abstract

Leiomyosarcoma (LMS) is an extremely rare malignant pathology affecting smooth muscle cells, with the uterus being the predominant location of LMS. Its occurrence in the duodenum is rare, making it a diagnostic challenge for radiologists. Patients with duodenal LMS can present with very vague symptoms such as abdominal discomfort, loss of weight, or manifestations associated with internal gastrointestinal bleeding. In this case report, we have an 82-year-old female presenting with duodenal LMS, which is a very atypical location. An esophagogastroduodenoscopy and further workup revealed a duodenal mass, which was biopsied. The lump was identified as an LMS using immunohistochemistry and histopathology. Despite its rarity, it presents diagnostic and therapeutic challenges due to its nonspecific clinical manifestations and radiological findings. By exploring the existing literature and clinical insights, we aim to provide a comprehensive understanding of this rare condition, highlighting the need for interdisciplinary collaboration and tailored therapeutic strategies to diagnose and manage this disease entity effectively.