# Discoloration and Dilemma: A Case Report of Hand-Foot Syndrome Associated With Capecitabine Use

## TL;DR

A 56-year-old cancer patient developed hand-foot syndrome after using capecitabine, a chemotherapy drug.

## Contribution

This case report documents a rare side effect of capecitabine, hand-foot syndrome, in a rectosigmoid carcinoma patient.

## Key findings

- The patient showed discoloration of palms, soles, and tongue during capecitabine treatment.
- A biopsy revealed chronic, nonspecific dermatitis linked to the drug.
- Hand-foot syndrome with capecitabine remains under-researched.

## Abstract

This case highlights the occurrence of hand-foot syndrome due to the use of an antimetabolite group of drugs, capecitabine, which was used in the chemotherapy of a 56-year-old male patient who was diagnosed with rectosigmoid carcinoma. The patient was diagnosed with rectosigmoid carcinoma two months ago and underwent laparoscopic lower anterior resection and colorectal anastomosis. Subsequently, the patient commenced chemotherapy treatment with a combination of oxaliplatin and capecitabine. The patient presented to us with complaints of loose stools for the past three days, and discoloration of the palms, soles, and tongue was noted and subjected to a biopsy, which revealed features compatible with chronic, nonspecific dermatitis. The occurrence of such palmar-plantar erythrodysesthesia with capecitabine is yet to be extensively studied.