# Gastrointestinal Alpha Heavy Chain Disease With Persistent Campylobacter Jejuni Colonization and Refractory Giardiasis

## TL;DR

This paper describes a rare case of a gastrointestinal lymphoma variant linked to persistent bacterial and parasitic infections.

## Contribution

The study reports a rare case of GI αHCD with multiple concurrent pathogens, including persistent Campylobacter jejuni and refractory giardiasis.

## Key findings

- GI αHCD was associated with persistent Campylobacter jejuni colonization.
- The patient also had refractory giardiasis, indicating a complex infection profile.
- Five concomitant pathogens were identified using a GI multiplex PCR panel.

## Abstract

Alpha heavy chain disease (αHCD) is a rare variant of the mucosa-associated lymphoid tissue lymphoma characterized by expression of a monotypic truncated immunoglobulin α heavy chain. αHCD frequently involves the gastrointestinal (GI) tract, and its pathogenesis has been linked to clonal B-cell expansion from chronic immune stimulation by infectious agents. We report a rare case of GI αHCD with 5 concomitant pathogens identified on a GI multiplex real-time polymerase chain reaction panel, featured by persistent Campylobacter jejuni colonization and refractory giardiasis.