# Case Report: Plummer's adenoma in Prader–Willi syndrome

## TL;DR

A 9-year-old boy with Prader–Willi syndrome developed Plummer's adenoma, a rare thyroid condition, which was confirmed through surgery and pathology.

## Contribution

This is the first reported case of Plummer's adenoma in a child with Prader–Willi syndrome.

## Key findings

- Plummer's adenoma was diagnosed in a 9-year-old boy with Prader–Willi syndrome through clinical and pathological evaluations.
- Surgery confirmed the diagnosis and is recommended as the treatment for younger children with this condition.
- Further research is needed to explore the possible link between Plummer's adenoma and Prader–Willi syndrome.

## Abstract

Thyroid nodules in children are less common than in adults but they are approximately two- to three-fold more likely to be malignant in children. Among thyroid nodular diseases, Plummer's adenoma occurs very rarely in pediatrics, and currently, there is no literature providing evidence of this diagnosis in patients with Prader–Willi syndrome (PWS). We report the case of a 9-year-old Caucasian boy affected by PWS presenting with a rapidly growing palpable mass in the thyroid lodge associated with subclinical hyperthyroidism. Laboratory and other examinations (thyroid ultrasound, fine-needle aspiration of the nodule, and scintigraphy) were strongly suggestive for Plummer's adenoma; therefore, the patient underwent left hemithyroidectomy surgery, and anatomo-pathological examination confirmed the diagnosis. Our case describes the first evidence of an isolated follicular adenoma in children with PWS. Surgery is the only therapeutic option in younger children. Further evidence is needed to assess the possible correlation between these two conditions and the existence of potential risk factors.