Research Progress on the Role of GSDME-mediated Pyroptosis in the Treatment of Lung Cancer
Huan LI, Xudong TANG
TL;DR
This paper reviews how GSDME-mediated cell death could offer new treatment options for lung cancer.
Contribution
Summarizes recent advances in understanding GSDME's role in lung cancer therapy and its potential side effects.
Findings
GSDME-mediated pyroptosis shows potential in regulating lung cancer growth.
GSDME methylation impacts lung cancer treatment outcomes.
The role of GSDME in the tumor microenvironment is increasingly understood.
Abstract
目前肺癌对人类健康构成了巨大威胁。尽管有关肺癌的治疗技术近年有了显著提高，但肺癌患者的5年生存率仍然不高。在此背景下，细胞焦亡（pyroptosis）这一独特的细胞死亡机制的发现，为探索肺癌治疗的新途径提供了全新的视角。特别是成孔蛋白E（gasdermin E, GSDME）在细胞焦亡过程中扮演的角色，提示其在肺癌治疗中具有巨大的应用潜力。近年来，GSDME介导的细胞焦亡在肺癌生长、肺癌微环境中的调节作用及GSDME甲基化对肺癌治疗影响的研究取得了较大的进展，本文对这些研究进展进行了总结，并对GSDME介导的细胞焦亡在肺癌治疗中的潜力及潜在的副作用进行了分析，旨在为开发更有效的肺癌治疗策略提供理论基础。
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Taxonomy
TopicsSulfur Compounds in Biology · Inflammasome and immune disorders · Heme Oxygenase-1 and Carbon Monoxide