# Forkhead Box O (FOXO) signaling in NSCLC: pathways to targeted therapies

**Authors:** Lakshmi Thangavelu, Terezinha de Jesus Andreoli Pinto, Sachchidanand Pathak, Abhishek Tiwari, Varsha Tiwari, Gaurav Gupta, Kumud Pant, Saurabh Gupta, Moyad Shahwan

PMC · DOI: 10.17179/excli2024-7272 · 2024-05-31

## Full-text entities

- **Genes:** EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, IGFBP1 (insulin like growth factor binding protein 1) [NCBI Gene 3484] {aka AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1}, PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) [NCBI Gene 5295] {aka AGM7, GRB1, IMD36, p85, p85-ALPHA, p85alpha}, MDM2 (MDM2 proto-oncogene) [NCBI Gene 4193] {aka ACTFS, HDMX, LSKB, hdm2}, DNMT3B (DNA methyltransferase 3 beta) [NCBI Gene 1789] {aka FSHD4, ICF, ICF1, M.HsaIIIB}, EPS8 (EGFR pathway substrate 8, signaling adaptor) [NCBI Gene 2059] {aka DFNB102}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, FOXO3 (forkhead box O3) [NCBI Gene 2309] {aka AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A}, FOXO1 (forkhead box O1) [NCBI Gene 2308] {aka FKH1, FKHR, FOXO1A}, STAT3 (signal transducer and activator of transcription 3) [NCBI Gene 6774] {aka ADMIO, ADMIO1, APRF, HIES}
- **Diseases:** cancer (MESH:D009369), lung cancer (MESH:D008175), lung carcinogenesis (MESH:D063646), non-small-cell lung cancer (MESH:D002289)
- **Chemicals:** Cisplatin (MESH:D002945), beta-Elemene (MESH:C445979), PM10 (-), gefitinib (MESH:D000077156)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC11333701