# Bacterial nanotechnology as a paradigm in targeted cancer therapeutic delivery and immunotherapy

## TL;DR

This review explores how bacteria and their components can be used in nanotechnology to improve cancer treatments and boost the immune system.

## Contribution

The paper introduces bacterial nanotechnology as a novel and multifunctional platform for targeted cancer therapy and immunotherapy.

## Key findings

- Bacteria can act as living carriers for delivering therapeutic agents to cancer cells.
- Bacterial components can stimulate the immune system to fight tumors.
- Bacteria-derived nano-drugs can synergize with technologies like CRISPR-Cas for enhanced cancer treatment.

## Abstract

Cancer, a multifaceted and diverse ailment, presents formidable obstacles to traditional treatment modalities. Nanotechnology presents novel prospects for surmounting these challenges through its capacity to facilitate meticulous and regulated administration of therapeutic agents to malignant cells while concurrently modulating the immune system to combat neoplasms. Bacteria and their derivatives have emerged as highly versatile and multifunctional platforms for cancer nanotherapy within the realm of nanomaterials. This comprehensive review delves into the multifaceted and groundbreaking implementations of bacterial nanotechnology within cancer therapy. This review encompasses four primary facets: the utilization of bacteria as living conveyors of medicinal substances, the employment of bacterial components as agents that stimulate the immune system, the deployment of bacterial vectors as tools for delivering genetic material, and the development of bacteria-derived nano-drugs as intelligent nano-medications. Furthermore, we elucidate the merits and modalities of operation pertaining to these bacterial nano-systems, along with their capacity to synergize with other cutting-edge nanotechnologies, such as CRISPR-Cas systems. Additionally, we offer insightful viewpoints regarding the forthcoming trajectories and prospects within this expanding domain. It is our deduction that bacterial nanotechnology embodies a propitious and innovative paradigm in the realm of cancer therapy, which has the potential to provide numerous advantages and synergistic effects in enhancing the outcomes and quality of life for individuals afflicted with cancer.