# Advances of Fundamental Research on Traditional Chinese Medicine in Regulation of Tumor-associated Macrophages for the Prevention and Treatment of Lung Cancer Metastasis

## TL;DR

This paper reviews how traditional Chinese medicine can regulate tumor-associated macrophages to prevent lung cancer metastasis.

## Contribution

It systematically summarizes the mechanisms and targets of traditional Chinese medicine in modulating TAMs for lung cancer treatment.

## Key findings

- Traditional Chinese medicine compounds can inhibit M2-type TAMs and reduce tumor metastasis.
- Regulation of TAMs by TCM affects tumor microenvironment and cytokine balance.
- TCM shows potential in preventing lung cancer progression through immune modulation.

## Abstract

肺癌是全球死亡率最高的癌种，而转移则是导致肺癌患者死亡的主要原因，且防控效率不高。近年来研究发现，免疫疗法或许是突破转移瓶颈的方向。巨噬细胞作为固有免疫的重要组成部分，参与肿瘤发生发展的全过程。肿瘤相关巨噬细胞（tumor-associated macrophages, TAMs）是肿瘤微环境（tumor microenvironment, TME）中最丰富的免疫群体，具有抗肿瘤的M1型和促肿瘤的M2型，后者通过促进肿瘤侵袭和转移、血管和淋巴管生成、免疫抑制和介导播散肿瘤细胞（disseminated tumor cells, DTCs）休眠重激活等途径促进肿瘤转移。近年来，中医药抑制肿瘤转移疗效显著并得到诸多验证，它能通过减少TAMs的募集、抑制M2型极化和调节TME中的细胞因子和蛋白发挥抗肿瘤作用。本文综述了TAMs与肺癌转移之间的关系，梳理了中医药调控TAMs防治肺癌转移的靶点与机制，以期为肺癌防治提供思路。

Fundamental research on the regulation of tumor-associated macrophages to inhibit lung cancer metastasis by traditional Chinese medicine compounds and monomers