# Second Child After Pregnancy and Lactation-Related Osteoporosis (PLO) Treated With Teriparatide: A Case Report

**Authors:** Shinsuke Yamada, Noriyuki Hayashi, Norikazu Toi, Daichi Miyaoka, Motomu Hashimoto

PMC · DOI: 10.7759/cureus.64900 · Cureus · 2024-07-19

## TL;DR

A woman with pregnancy-related osteoporosis successfully had a second child after treatment with teriparatide, showing the condition can be managed.

## Contribution

This case report demonstrates successful PLO treatment and a safe subsequent pregnancy using teriparatide.

## Key findings

- The patient received teriparatide and had no PLO recurrence during her second pregnancy.
- She delivered a healthy child at age 33 after treatment.
- More case studies are needed to confirm treatment efficacy and safety.

## Abstract

Pregnancy and lactation-associated osteoporosis (PLO) is one of the rarest and most serious primary osteoporotic conditions that develops during the third trimester of gestation and/or early postpartum period. A history of PLO often causes individuals to hesitate when considering an additional child due to anxiety about recurrence risk. Reported here are details of a 29-year-old patient with PLO given aggressive treatment for osteoporosis with teriparatide who subsequently gave birth to a healthy child at age 33 without PLO recurrence. Further case studies are needed to examine the efficacy and safety of PLO treatment and to provide beneficial results for those who wish to have another pregnancy.

## Linked entities

- **Chemicals:** teriparatide (PubChem CID 16133850)
- **Diseases:** Pregnancy and lactation-associated osteoporosis (MONDO:0100194), osteoporosis (MONDO:0005298)

## Full-text entities

- **Diseases:** PLO (MESH:C535932), Osteoporosis (MESH:D010024), Pregnancy and lactation-associated osteoporosis (MESH:D020150), anxiety (MESH:D001007), primary osteoporotic conditions (MESH:D058866)
- **Chemicals:** Teriparatide (MESH:D019379)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11330588/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC11330588/full.md

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Source: https://tomesphere.com/paper/PMC11330588