# A Unique Case of Unprovoked Pulmonary Venous Thrombosis in a Postpartum Female Following COVID-19 Infection

**Authors:** Jordan Lipschutz, Sophia H Ji, Mohammad Q Jafri, Ambica Nair, Brian Kerr

PMC · DOI: 10.7759/cureus.64893 · Cureus · 2024-07-19

## TL;DR

A postpartum woman developed unprovoked pulmonary venous thrombosis after a mild case of COVID-19, highlighting the virus's potential to cause blood clots.

## Contribution

Reports a rare case of post-COVID-19 pulmonary venous thrombosis in a postpartum woman without other risk factors.

## Key findings

- The patient had unprovoked PVT following a nonhospitalized COVID-19 infection.
- Imaging confirmed PVT with ground glass infiltrates despite a negative hypercoagulable workup.
- Treatment with heparin and apixaban led to thrombus resolution, emphasizing the need for vigilance in post-COVID patients.

## Abstract

SARS-CoV-2 can induce a hypercoagulable state, occasionally resulting in pulmonary venous thrombosis (PVT) due to inflammation and endothelial injury. Documented cases of PVT with active COVID-19 and post-COVID are rare. We report a 40-year-old postpartum female with unprovoked PVT following a recent nonhospitalized COVID-19 infection. She presented with cough, right pleuritic chest pain, and worsening dyspnea. Imaging confirmed right lower lobe PVT with ground glass infiltrates. Despite a negative hypercoagulable workup, the patient’s postpartum and post-COVID status suggest an unprovoked PVT. Treated with a high-intensity heparin drip and transition to apixaban, she showed resolution of the thrombus. This case underscores the importance of considering COVID-19 as a potential risk factor for venous thromboembolism and highlights the need for vigilant monitoring in post-COVID-19 patients.

## Linked entities

- **Chemicals:** apixaban (PubChem CID 10182969)
- **Diseases:** SARS-CoV-2 (MONDO:0100096), COVID-19 (MONDO:0100096)

## Full-text entities

- **Diseases:** venous thromboembolism (MESH:D054556), COVID-19 (MESH:D000086382), PVT (MESH:D020246), chest pain (MESH:D002637), injury (MESH:D014947), dyspnea (MESH:D004417), cough (MESH:D003371), inflammation (MESH:D007249), hypercoagulable (MESH:D019851), post-COVID (MESH:D000094024), thrombus (MESH:D013927)
- **Chemicals:** heparin (MESH:D006493), apixaban (MESH:C522181)
- **Species:** Homo sapiens (human, species) [taxon 9606], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11330582/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC11330582/full.md

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Source: https://tomesphere.com/paper/PMC11330582