# Platelet-Rich Fibrin: A Self-Derived Biomaterial for Surgical Treatment of a Periapical Lesion

## TL;DR

This case report shows that platelet-rich fibrin (PRF) can help heal a dental cyst after surgery, offering a cost-effective and regenerative treatment option.

## Contribution

The study demonstrates the successful use of PRF in surgical treatment of a persistent periapical lesion after failed endodontic therapy.

## Key findings

- PRF use in surgery led to successful healing with no inflammation or discomfort at follow-ups.
- PRF provided a favorable environment for tissue remodeling and wound healing.
- The procedure included enucleation, apicoectomy, and retrograde filling with Biodentine.

## Abstract

This case report explores the application of platelet-rich fibrin (PRF) as an autologous biomaterial in the surgical management of a periapical cyst in an 18-year-old female patient. The patient presented with pain, discoloration, and swelling in the maxillary left central incisor region, indicative of an asymptomatic periapical lesion associated with a history of trauma. Despite initial endodontic treatment with calcium hydroxide, the lesion persisted, necessitating surgical intervention.

PRF, prepared from the patient’s blood, was utilized during periapical surgery to promote healing and tissue regeneration. The surgical procedure included enucleation of the cyst, apicoectomy, and retrograde filling with Biodentine. Clinical and radiographic assessments at follow-up visits (three, six, and nine months post-surgery) revealed successful healing with no signs of inflammation or discomfort.

The use of PRF demonstrated favorable outcomes in enhancing wound healing and maintaining a favorable environment for tissue remodeling. This case underscores the potential of PRF as an effective biomaterial in periapical surgery, advocating for its integration into dental therapeutic strategies for its regenerative properties and cost-effectiveness.