# Handshaking for ultrafast endocytosis: Dynamin1xA and Endophilin A1 sealed the deal

## TL;DR

This study explains how neurons can rapidly recycle synaptic components through preassembled protein machinery.

## Contribution

The paper discovers a novel interaction between Dynamin1xA and Endophilin A1 that enables ultrafast endocytosis.

## Key findings

- A regulated interaction between Dynamin1xA and Endophilin A1 was identified.
- This interaction supports preassembled machinery for ultrafast endocytosis at synapses.

## Abstract

Brain function relies on quick inter-neuron communication at specialized points of contact termed synapses. In the latest issue of The EMBO Journal, Imoto, Xue, et al (2024) report the discovery of a novel, regulated interaction between two major endocytosis players which supports the notion of a preassembled protein machinery at presynaptic nerve terminals that can explain how the high speed of ultrafast endocytosis is possible.

A new study reveals how preassembled components at the endocytic zone permit ultrafast endocytosis to occur so quickly.