# Are maternal serum subfatin levels altered in women with one abnormal glucose tolerance test value?

## TL;DR

This study investigates whether subfatin levels in pregnant women are affected by abnormal glucose tolerance test results.

## Contribution

The study explores subfatin levels in women with one abnormal glucose tolerance test value, a novel focus in gestational diabetes research.

## Key findings

- Serum subfatin levels were significantly lower in women with gestational diabetes compared to controls.
- The triglyceride/high-density lipoprotein cholesterol ratio was lower in the healthy control group.
- Women with one abnormal glucose tolerance test value showed altered triglyceride/high-density lipoprotein cholesterol ratios.

## Abstract

Subfatin, a newly discovered adipokine, plays a pivotal role in the regulation of glucose metabolism. The relationship between gestational diabetes mellitus and maternal dyslipidemia is well-documented.

This study aims to assess serum subfatin levels and the triglyceride/high-density lipoprotein cholesterol ratio in women with one abnormal glucose tolerance test value and those with gestational diabetes mellitus.

In this case-control study, 105 pregnant women were categorized into three groups: women with normal 3-h oral glucose tolerance test results (n=35), women with one abnormal 3-h oral glucose tolerance test result (n=35), and women diagnosed with gestational diabetes mellitus (n=35). Serum subfatin levels were measured using human enzyme-linked immunosorbent assay kits.

Serum subfatin levels were significantly lower in the gestational diabetes mellitus group (0.94±0.15 ng/mL) compared to the normal oral glucose tolerance test group (1.48±0.55 ng/mL) and the group with one abnormal oral glucose tolerance test result (1.50±0.59 ng/mL). The triglyceride/high-density lipoprotein cholesterol ratio was also lower in the healthy control group than in the gestational diabetes mellitus and one abnormal oral glucose tolerance test result groups.

Serum subfatin levels in women with one abnormal abnormal glucose tolerance test value are compared to those in the control group, while the triglyceride/high-density lipoprotein cholesterol ratio is significantly altered in women with one abnormal abnormal glucose tolerance test value when compared to the control group.