# Cogent integration of inflammatory biomarkers and perioperative complications of thyroid surgery in thyroidology

## TL;DR

This study examines the link between inflammatory biomarkers and perioperative complications in thyroid surgery, finding no significant predictive value.

## Contribution

The study contributes by showing that preoperative inflammatory biomarkers do not reliably predict perioperative complications in thyroid surgery.

## Key findings

- No significant relationship was found between preoperative biomarkers and complications like hypoxemia or hypotension.
- Platelet-to-lymphocyte ratio showed a high but non-significant correlation with hypoxemia and hypotension.
- No significant associations were found between laboratory values and bradycardia, hypertension, or postoperative nausea and vomiting.

## Abstract

Back to the sources, postoperative nausea and vomiting, hypo- and hypertension, heart rate alterations, and hypoxemia due to laryngospasm might be considered perioperative complications.

This cross-sectional study was conducted at an Education and Research Hospital between January 2018 and June 2023. The study included a total of 437 cases of thyroid surgery. The demographic data such as age, sex, co-morbidities of the instances, hypotension, hypertension, bradycardia, hypoxemia, and postoperative nausea and vomiting, as well as laboratory data were obtained and analyzed.

Of 437 cases, 334 (76%) were females and 103 (24%) were males, with a mean age of 51.83±11.91 years and 55.32±11.87 years, respectively. No statistical significance was realized between the complications, co-morbid diseases, and age. Notably, no liaison between the complications after awakening from the anesthesia and preoperative laboratory parameters was discerned. However, a high but no significant relationship was revealed between the platelet-to-lymphocyte ratio (P/L) in cases with hypoxemia and hypotension. Finally, no significance between laboratory values, bradycardia, hypertension, and postoperative nausea and vomiting was distinguished.

We postulate that the so-called inflammatory biomarkers measured at the time of preoperative examination in the blood count concept selectively do not enrich for anticipating complications that arise in the perioperative echelon.