# Sister Mary Joseph Syndrome: A Report of a Rare Case

## TL;DR

This paper reports a rare case of Sister Mary Joseph syndrome in a woman with endometrial cancer, highlighting its poor prognosis and diagnostic process.

## Contribution

The novelty lies in presenting a detailed clinical case of a rare syndrome linked to abdominopelvic cancer.

## Key findings

- Sister Mary Joseph syndrome was diagnosed via umbilical biopsy in a patient with endometrioid adenocarcinoma.
- The patient is undergoing palliative chemotherapy due to the poor prognosis associated with the syndrome.

## Abstract

The Sister Mary Joseph syndrome is characterized by cutaneous metastases localized at the umbilical level. It is a rare clinical sign estimated to occur in 1%-3% of patients with abdominopelvic cancer. The most common histology is adenocarcinoma (75% of cases). The presence of this nodule is often indicative of a poor prognosis, with average survival estimated at two to 11 months without treatment. We report the clinical case of Sister Mary Joseph syndrome in a 50-year-old woman who had been followed for three years for endometrioid adenocarcinoma of the endometrium. The diagnosis was established via umbilical biopsy after a computed tomography scan revealed the presence of an umbilical nodule. The patient is currently undergoing a palliative chemotherapy regimen.