# Simultaneous detection of methylation and genetic variations of BCR-ABL1 gene by nanopore Cas9-targeted sequencing

**Authors:** Shuilian Xie, Ying Yang, Junjie Zhang, Menglin Zhu, Wang Li, Mengting Li, Yijian Chen, Hailiang Li, Weidan Lun, Weelic Chong, Shaogui Wan

PMC · DOI: 10.1016/j.gendis.2023.101190 · Genes & Diseases · 2023-12-06

## Full-text entities

- **Genes:** LGR5 (leucine rich repeat containing G protein-coupled receptor 5) [NCBI Gene 8549] {aka FEX, GPR49, GPR67, GRP49, HG38}, ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) [NCBI Gene 25] {aka ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL}, BCR (BCR activator of RhoGEF and GTPase) [NCBI Gene 613] {aka ALL, BCR1, CML, D22S11, D22S662, PHL}, HTT (huntingtin) [NCBI Gene 3064] {aka HD, IT15, LOMARS}, LIPC (lipase C, hepatic type) [NCBI Gene 3990] {aka HDLCQ12, HL, HTGL}
- **Diseases:** Huntington disease (MESH:D006816), leukemia (MESH:D007938)
- **Chemicals:** phosphate (MESH:D010710), deoxyribose (MESH:D003855), 5-methylcytosine (MESH:D044503)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** K562 — Homo sapiens (Human), Blast phase chronic myelogenous leukemia, BCR-ABL1 positive, Cancer cell line (CVCL_0004)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11327521/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11327521/full.md

## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC11327521/full.md

---
Source: https://tomesphere.com/paper/PMC11327521