Editorial Note: Global Gene Expression Analysis of Canine Osteosarcoma Stem Cells Reveals a Novel Role for COX-2 in Tumour Initiation

Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsCancer Cells and Metastasis · Virus-based gene therapy research · Veterinary Oncology Research
Following the publication of this article [1], concerns were raised that the Fig 1G Fibronectin results of [1] appears similar to the Fig 1D Fibronectin result of [2] despite being used to represent results from different cell lines.
The corresponding author stated that the Fig 1G Fibronectin results were correctly reported in the PLOS ONE article [1] but were inadvertently duplicated in [2]. They stated that all cell lines were blotted together, and that the incorrect lanes were selected when preparing the Fibronectin results presented in [2].
The available original data underlying Fig 1 [1] are provided in S1–S5 Files. The original blot image underlying the Fig 1G β-catenin panel is no longer available. The authors did not clarify the availability of the remaining data.
The PLOS ONE Editors issue this Editorial note to notify readers of the above concern, which PLOS considers resolved, and to share the available original data for Fig 1 that have been provided by the corresponding author.
Supporting information
S1 FileOriginal data underlying Fig 1A and 1B.(PPTX)
S2 FileOriginal data underlying Fig 1D.(PPTX)
S3 FileIndividual level data underlying Fig 1E.(XLS)
S4 FileOriginal data underlying Fig 1F.(PPTX)
S5 FileOriginal data underlying Fig 1G.(PPTX)
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Pang LY, Gatenby EL, Kamida A, Whitelaw BA, Hupp TR, Argyle DJ (2014) Global Gene Expression Analysis of Canine Osteosarcoma Stem Cells Reveals a Novel Role for COX-2 in Tumour Initiation. P Lo S ONE 9(1): e 83144. doi: 10.1371/journal.pone.0083144 24416158 PMC 3885401 · doi ↗ · pubmed ↗
- 2Pang LY, Saunders Argyle DJ (2017) Epidermal growth factor receptor activity is elevated in glioma cancer stem cells and is required to maintain chemotherapy and radiation resistance. Oncotarget 8: 72494–72512. doi: 10.18632/oncotarget.19868 29069805 PMC 5641148 · doi ↗ · pubmed ↗
