# Unravelling the Enigma of Ocular Complexity: Delving into Aniridia, Xerophthalmia, Corneal Ulcer, Keratomalacia, and Beyond

**Authors:** Renu Magdum, Rutu K Rao, Aditya Ganesh, Neha Chaudhary, Vishakha Vatkar

PMC · DOI: 10.7759/cureus.64631 · Cureus · 2024-07-16

## TL;DR

This case report describes a rare combination of eye conditions in a young adult and emphasizes the need for a holistic treatment approach.

## Contribution

The paper presents a unique case of multiple rare ocular conditions occurring simultaneously and their integrated management.

## Key findings

- The patient exhibited aniridia, xerophthalmia, corneal ulcer, and keratomalacia in a rare combination.
- Personalized treatment strategies improved patient outcomes by addressing the interplay of multiple pathologies.
- The case highlights the importance of a comprehensive approach in managing complex ocular conditions.

## Abstract

In this case report, we explore a complex and rare presentation of simultaneous aniridia, xerophthalmia, corneal ulcer, and keratomalacia in a 21-year-old patient with a congenital history of nystagmus and progressively diminishing visual acuity. The patient experienced a recent exacerbation of ocular pain and redness, primarily in the right eye, which led to a comprehensive ophthalmological evaluation. Examination revealed corneal ulceration, vascularization, and the absence of the iris, posing a unique clinical challenge. In this report, we detail the personalized management and therapeutic strategies employed in this case, emphasising the need for an integrated and holistic approach to treating complex ocular conditions. The outcomes highlight the importance of tailored treatment plans and a thorough understanding of the interplay between various eye pathologies to achieve better patient outcomes.

## Linked entities

- **Diseases:** aniridia (MONDO:0019172), xerophthalmia (MONDO:0000948), corneal ulcer (MONDO:0004577), keratomalacia (MONDO:0001250), nystagmus (MONDO:0005712)

## Full-text entities

- **Diseases:** nystagmus (MESH:D009759), Xerophthalmia (MESH:D014985), ocular pain (MESH:D058447), Corneal Ulcer (MESH:D003320), Aniridia (MESH:D015783), Keratomalacia (MESH:C536156)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11325210/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC11325210/full.md

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Source: https://tomesphere.com/paper/PMC11325210