# Haemostatic spray in the management of acute nonvariceal upper gastrointestinal bleeding in children: A single‐centre experience in Singapore

## TL;DR

This study shows that a hemostatic spray is effective and safe for treating acute upper gastrointestinal bleeding in children.

## Contribution

The study provides new evidence on the efficacy and safety of hemostatic spray in pediatric patients.

## Key findings

- 100% initial hemostasis was achieved in 25 applications of hemostatic spray.
- 13% of patients experienced re-bleeding, with no adverse events reported.
- Hemostatic spray was used as monotherapy in 68% of cases and was well tolerated.

## Abstract

Haemostatic spray (HS; Hemospray) is a powder agent for endoscopic haemostasis in patients with acute upper gastrointestinal bleeding (UGIB). It has been shown to be effective and easy to administer. However, published data on efficacy and safety in children remain scarce. Our aim was to describe our experience with the use of HS in the management of UGIB.

A retrospective review was conducted of patients aged 0–18 receiving HS for endoscopic haemostasis from January 2017 to December 2021. Information was obtained on demographics, clinical presentation and comorbidities. Outcomes were successful initial haemostasis and rates of re‐bleeding.

A total of 25 applications of HS occurred in 23 patients. The median patient age was 8 years (range: 4 months to 16 years). HS was used in 17/25 (68%) applications as monotherapy. Other treatments employed were clip application and adrenaline injection. One hundred per cent initial haemostasis was achieved with three (13.0%) patients who experienced re‐bleeding. All patients tolerated HS applications with no adverse events.

Our finding supports the use of HS in the management of UGIB in children. HS, either as monotherapy or in combination with other conventional therapy, could potentially be the treatment of choice in children with UGIB with its excellent feasibility and good safety profile.

Haemostatic spray (HS) has been shown to be effective and easy to administer for endoscopic haemostasis in patients with acute upper gastrointestinal bleeding (UGIB).It has the potential to improve outcomes of acute UGIB in children.

Haemostatic spray (HS) has been shown to be effective and easy to administer for endoscopic haemostasis in patients with acute upper gastrointestinal bleeding (UGIB).

It has the potential to improve outcomes of acute UGIB in children.

HS was highly efficacious in the treatment of paediatric acute UGIB, either as monotherapy or in combination with other conventional therapies.100% initial haemostasis was achieved with a 13% re‐bleeding rate.No adverse events were encountered.

HS was highly efficacious in the treatment of paediatric acute UGIB, either as monotherapy or in combination with other conventional therapies.

100% initial haemostasis was achieved with a 13% re‐bleeding rate.

No adverse events were encountered.