Drug-Induced Angioedema Without Urticaria: A Case Report

TL;DR

This case report describes a rare but serious allergic reaction to a common painkiller, highlighting the importance of quick diagnosis and treatment.

Contribution

The paper presents a new clinical case of angioedema caused by diclofenac, emphasizing its management and pathogenesis.

Findings

Diclofenac can cause life-threatening angioedema without urticaria.

Prompt drug cessation and corticosteroid/antihistamine treatment are critical.

Leukotriene production and mast cell degranulation are key in the reaction's pathogenesis.

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for various conditions but are associated with numerous adverse drug reactions (ADRs). Understanding these ADRs is necessary to reduce morbidity and mortality. NSAID-induced angioedema, although rare, can be life-threatening and is often due to increased leukotriene production from COX pathway inhibition. Mast cells and basophil degranulation play vital roles in its pathogenesis. Prompt recognition and immediate cessation of the culprit drug, along with the administration of corticosteroids and antihistamines, are essential. Here, we report a case of angioedema caused by diclofenac administration, which needs prompt vigilance and a rapid therapeutic response.

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