# A Chicken-and-Egg Predicament: Malignant Hypertension Versus HIV-Induced Thrombotic Microangiopathic Anemia Conundrum

**Authors:** Daniel Zamanian, Akshat Agrawal, Arpita Pawa, Hector J Brunet-Rodriguez, Sreedhara Alla

PMC · DOI: 10.7759/cureus.64304 · 2024-07-11

## TL;DR

This paper discusses a case where a man's TMA could be caused by either malignant hypertension or HIV, highlighting the need for comprehensive diagnosis.

## Contribution

The novelty lies in examining the potential link between malignant hypertension and HIV in causing TMA.

## Key findings

- A 39-year-old male presented with secondary TMA.
- The case explores the roles of malignant hypertension and HIV in TMA development.
- The report emphasizes the importance of a broad diagnostic approach for TMA.

## Abstract

Thrombotic microangiopathy (TMA) is a condition characterized by hemolytic anemia, thrombocytopenia, and organ damage due to the formation of microthrombi. It can be classified as primary or secondary, with secondary TMA being associated with conditions such as infections, autoimmune diseases, and malignancies. This report details the case of a 39-year-old male with secondary TMA, exploring the potential roles of malignant hypertension and HIV infection with the aim of examining the potential link between malignant hypertension and HIV infection in the development of TMA, highlighting the need for a thorough and broad diagnostic approach.

## Linked entities

- **Diseases:** thrombotic microangiopathy (MONDO:0019737), malignant hypertension (MONDO:0006846)

## Full-text entities

- **Diseases:** HIV infection (MESH:D015658), Malignant Hypertension (MESH:D006974), infections (MESH:D007239), thrombocytopenia (MESH:D013921), organ damage (MESH:D000092124), malignancies (MESH:D009369), TMA (MESH:D057049), autoimmune diseases (MESH:D001327), Thrombotic Microangiopathic Anemia (MESH:D000743)
- **Species:** Human immunodeficiency virus 1 (no rank) [taxon 11676]

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11316243/full.md

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Source: https://tomesphere.com/paper/PMC11316243