# Metformin-Induced Nightmares: An Uncommon Event

**Authors:** Bosky Modi, Devi P Suravajjala, James Case, Priya Velumani

PMC · DOI: 10.7759/cureus.64251 · Cureus · 2024-07-10

## TL;DR

This paper reports a rare case where metformin, a common diabetes drug, caused recurring nightmares in a 72-year-old man.

## Contribution

The novelty lies in documenting metformin-induced nightmares, a previously uncommonly reported adverse effect.

## Key findings

- A 72-year-old male with type 2 diabetes experienced recurrent nightmares after starting metformin.
- Nightmares ceased after discontinuation of metformin, suggesting a possible causal relationship.
- The mechanism behind metformin-induced nightmares remains poorly understood.

## Abstract

Metformin is well-known in the treatment of type 2 diabetes mellitus (DM). Metformin has become a drug of choice due to its affordability, cost-effectiveness, and established safety record. It primarily works by inhibiting hepatic gluconeogenesis. Common side effects include gastrointestinal issues, with rare complications, such as lactic acidosis and vitamin B12 malabsorption. This study discussed a 72-year-old male with type 2 DM who experienced recurrent nightmares upon initiating metformin, which ceased after discontinuation. The mechanism of metformin-associated nightmares remains poorly understood. Despite metformin's benefits, this case highlights the importance of recognizing rare adverse effects like nightmares, which can significantly impact patients' quality of life.

## Linked entities

- **Chemicals:** metformin (PubChem CID 4091)
- **Diseases:** type 2 diabetes mellitus (MONDO:0005148), lactic acidosis (MONDO:0006040)

## Full-text entities

- **Diseases:** type 2 DM (MESH:D003924), DM (MESH:D003920), lactic acidosis (MESH:D000140), gastrointestinal (MESH:D005767), vitamin B12 malabsorption (MESH:D014806)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC11314689/full.md

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Source: https://tomesphere.com/paper/PMC11314689