# Thermodynamic Studies of Complexes in Cu(II)/Uridine-5′-Diphosphoglucuronic Acid System

## TL;DR

This paper studies how copper (II) ions interact with a specific biomolecule, finding that their complexes show increased biological activity, possibly useful for cancer treatment.

## Contribution

The study introduces new insights into the thermodynamic properties and biological activity of Cu(II)/uridine-5′-diphosphoglucuronic acid complexes.

## Key findings

- The stability and formation constants of complexes in the Cu(II)/uridine-5′-diphosphoglucuronic acid system were determined.
- Spectroscopic analysis revealed the coordination mode of the complexes.
- The complexes showed higher biological activity compared to the free ligand.

## Abstract

A binary system of uridine-5′-diphosphoglucuronic acid with copper (II) ions was studied. Potentiometric studies in aqueous solutions using computer data analysis were carried out. The pH of dominance, the overall stability constants (logβ), and the equilibrium constants of the formation reaction (logKe) were determined for each complex compound formed in the studied system. Spectroscopic studies were carried out to determine the mode of coordination in the compounds studied. Cytotoxicity and metabolic activity tests of the compounds obtained showed an increase in the biological activity of the complexes tested against the free ligand. The current research may contribute to the knowledge of complex compounds of biomolecules found in the human body and may also contribute to the characterization of a group of complex compounds with potential anticancer properties.