# D-Hexopyranosides with Vicinal Nitrogen-Containing Functionalities

## TL;DR

This review summarizes the synthesis of D-hexopyranosides with nitrogen-containing groups, which are found in many natural and pharmaceutical compounds.

## Contribution

The paper provides a comprehensive overview of synthetic methods for D-hexopyranosides with vicinal nitrogen-containing functionalities since the 1960s.

## Key findings

- D-hexopyranosides with nitrogen-containing groups are important in natural and pharmaceutical compounds.
- The review organizes syntheses based on substitution positions and methodologies.
- These compounds exhibit diverse biological functions due to their structural variety.

## Abstract

Various substituted D-hexopypyranosides units with nitrogen-containing functionalities are present in many important natural compounds and pharmaceutical substances. Since their complex structural diversity contributes to a broad spectrum of biological functions and activities, these derivatives are frequently studied. This review covers syntheses of D-hexopyranosides with vicinal nitrogen-containing functionalities since the 1960s, when the first articles emerged. The syntheses are arranged according to the positions of substitutions, to form a relative configuration of vicinal functionalities, and synthetic methodologies.