# Psoriasis and Lupus Erythematosus—Similarities and Differences between Two Autoimmune Diseases

## TL;DR

This paper compares psoriasis and lupus, highlighting their differences and similarities in symptoms and treatment challenges.

## Contribution

The paper provides a detailed analysis of shared pathogenetic elements and therapeutic strategies for psoriasis and lupus.

## Key findings

- Psoriasis and lupus share some pathogenetic mechanisms despite being clinically distinct.
- Drugs for lupus can cause psoriatic lesions, and phototherapy for psoriasis can worsen lupus skin symptoms.
- The coexistence of both diseases remains a diagnostic and therapeutic challenge.

## Abstract

Systemic lupus erythematosus (SLE) and psoriasis (Ps) are two clinically distinct diseases with different pathogenesis. However, recent studies indicate some similarities in both clinical presentation and pathogenetic mechanisms. The coexistence of both entities is very uncommon and has not been fully elucidated. Thus, it remains a diagnostic and therapeutic challenge. In fact, drugs used in SLE can induce psoriatic lesions, whereas phototherapy effective in Ps is an important factor provoking skin lesions in patients with SLE. The aim of this work is to discuss in detail the common pathogenetic elements and the therapeutic options effective in both diseases.