# ABO/Rh Blood Group and Cervical Cancer Survival: Results from Our Own and Other Studies

## TL;DR

This study explores if blood types ABO and Rh affect cervical cancer survival, finding RhD-negative patients may have better survival and lower age at diagnosis.

## Contribution

The study contributes new data on the potential link between RhD blood group and cervical cancer survival, suggesting a possible prognostic role.

## Key findings

- RhD-negative patients had higher overall survival compared to RhD-positive patients.
- RhD-negative patients were diagnosed at a lower age than RhD-positive patients.
- Blood types B and AB were associated with higher BMI compared to other blood types.

## Abstract

Background: Cervical cancer is the most common genital cancer worldwide and is mainly caused by a persistent human papillomavirus infection. Well-known prognostic factors are age, histology, stage, stromal invasion, tumor size, and tumor grade. The relationship between the ABO and Rh system with cervical cancer has been studied since the 1950s, though without obtaining clear results. Here we investigated the association between the ABO blood group and Rh system and consecutively treated cervical cancer patients in our department.

Methods: Clinical charts of cervical cancer patients treated and followed from 2010 to 2021 were checked for inclusion and exclusion criteria. Clinical and pathological data were recorded in a separate, anonymous, password-protected electronic database. All relevant data were extrapolated and used for final analysis.

Results: A population of 143 cervical cancer patients was analyzed in this study. 47.6% (68/143) were blood group O, 36.4% (52/143) were blood group A, 8.4% (12/143) were blood group AB, and 7.7% (11/143) were blood group B. 14.9% (21/141) were RhD negative, while 85.1% (120/141) were RhD positive. No significant association was found between the ABO group and survival. However, patients with blood types B and AB had a higher BMI than the other blood types. RhD-negative patients exhibited a lower age at diagnosis (P=0.035) and had a higher overall survival compared to RhD-positive patients.

Conclusions: The RhD factor appears to influence cervical cancer OS, but the data are too weakly significant to draw a definitive conclusion. Further studies with larger samples are needed to confirm this finding and to investigate the true impact of blood groups in female cancers.