# Clinical analysis on the impact of pretransplant iron overload on allogeneic hematopoietic stem cell transplantation for patients with acquired severe aplastic anemia in pediatric

## TL;DR

This study examines how iron overload before a stem cell transplant affects outcomes in children with severe aplastic anemia.

## Contribution

The study reveals that pretransplant iron overload delays immune cell recovery and increases transplant complications in pediatric patients.

## Key findings

- Iron overload before transplantation is linked to longer disease duration and higher red blood cell transfusion needs.
- Iron overload delays the recovery of regulatory T cells after transplantation.
- It increases the risk of complications like hemorrhagic cystitis and severe graft-versus-host disease.

## Abstract

探讨铁过载对治疗重型再生障碍性贫血（SAA）患儿异基因造血干细胞移植（allo-HSCT）疗效的影响。通过对武汉儿童医院血液科2018年1月至2022年8月间接受allo-HSCT的74例SAA患儿的临床资料进行回顾性分析，发现移植前铁过载组［血清铁蛋白（SF）>1 000 µg/L］患儿移植前病程更长、红细胞输注量更大、回输CD34+细胞数更多，且铁过载显著延迟了移植后调节性T细胞（Treg细胞）的重建，增加了移植后出血性膀胱炎和Ⅲ～Ⅳ度急性移植物抗宿主病的发生率。然而，铁过载对患儿的总生存率和无失败生存率并无显著影响。