# Chinese expert consensus on minimal residual disease detection in multiple myeloma based on bone marrow samples（2024）

## TL;DR

This paper presents a Chinese expert consensus on using bone marrow-based MRD detection to improve multiple myeloma patient management.

## Contribution

The paper introduces a standardized consensus for MRD detection using NGF and NGS in multiple myeloma.

## Key findings

- NGF and NGS are the main techniques for MRD detection in bone marrow samples.
- Combining MRD detection with traditional assessments improves disease evaluation accuracy.
- The consensus aims to standardize MRD detection practices in China.

## Abstract

多发性骨髓瘤（MM）是血液系统第二大常见恶性肿瘤，标准的整体治疗模式及以新药为主的方案极大地改善了MM患者的生存，但微小残留病（MRD）导致大多数患者复发。因此，需要在传统血清学疗效评估的基础上联合MRD检测，以更精准地评估患者的疾病状态。目前，二代流式细胞术（NGF）和二代测序（NGS）是基于骨髓样本检测MRD的主流技术。为使MRD检测标准化和规范化，专家组讨论制订了在MM患者中应用NGF和NGS技术进行骨髓MRD检测的中国专家共识。