# Research progress of tumor-infiltrating lymphocytes in malignant hematological diseases

## TL;DR

This paper reviews the role and research progress of tumor-infiltrating lymphocytes in treating malignant blood cancers.

## Contribution

The paper provides a comprehensive overview of TIL composition, characteristics, and their application in hematological malignancies.

## Key findings

- TILs are heterogeneous T-cell-based lymphocytes crucial in the tumor microenvironment.
- TILs show strong specificity and effectiveness without requiring large IL-2 induction.
- TILs are gaining attention as a novel immunotherapy for hematological diseases.

## Abstract

近年来，免疫疗法在肿瘤治疗中进展迅速，其中免疫活性细胞的过继免疫治疗在恶性血液系统疾病的治疗中也越来越受到重视。肿瘤浸润性淋巴细胞（tumor-infiltrating lymphocyte，TIL）是一类以T细胞为主的异型淋巴细胞，具有高度异质性。作为肿瘤微环境的重要组成部分，TIL在恶性肿瘤的发生发展中至关重要。TIL是继淋巴因子激活杀伤细胞之后发现的一种新型免疫活性细胞，在不需要大量IL-2诱导的情况下即可展现出强特异性和有效性。本文就TIL的组成、特点和其在恶性血液系统疾病中的研究进展等进行综述。