# Case Report: Neurobrucellosis Presenting as Malignancy

**Authors:** Andrea S. Salcedo, Xosse Carreras, Takaaki Kobayashi, Jorge L. Salinas, Sara Muñoz, Nelson Diaz, Jorge Alave

PMC · DOI: 10.4269/ajtmh.23-0684 · The American Journal of Tropical Medicine and Hygiene · 2024-06-11

## TL;DR

A 25-year-old woman in Peru had a brain lesion initially suspected as cancer, but it was diagnosed as neurobrucellosis, a rare infection caused by Brucella.

## Contribution

This case report highlights neurobrucellosis as a rare differential diagnosis for brain masses in endemic regions.

## Key findings

- A brain biopsy showed non-necrotizing granulomas without malignancy.
- Serum testing confirmed Brucella infection.
- The patient's symptoms and imaging findings led to a correct diagnosis of neurobrucellosis.

## Abstract

Neurobrucellosis, caused by Brucella species, is a zoonotic infection that may involve the central nervous system. Although uncommon, it can manifest as a solitary intracranial mass. We report a case of neurobrucellosis in a 25-year-old woman from Peru who presented with headache, weight loss, and right-side hemiparesis and paresthesia. A contrast-enhanced magnetic resonance imaging scan revealed an intracerebral mass in the left temporal lobe. Serum testing subsequently were positive. Brain biopsy demonstrated non-necrotizing granulomas without malignant cells. Neurobrucellosis should be considered in the differential diagnosis of brain space occupying lesions in endemic countries.

## Linked entities

- **Species:** Brucella (taxon 234), Peru (taxon 1767537)

## Full-text entities

- **Diseases:** weight loss (MESH:D015431), paresthesia (MESH:D010292), hemiparesis (MESH:D010291), intracranial mass (MESH:C536030), infection (MESH:D007239), brain space occupying lesions (MESH:D001927), intracerebral mass (MESH:D002543), headache (MESH:D006261), granulomas (MESH:D006099)
- **Species:** Homo sapiens (human, species) [taxon 9606], Brucella (genus) [taxon 234]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11310615/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC11310615/full.md

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Source: https://tomesphere.com/paper/PMC11310615