# Focally Spared Region in Diffuse Type of Liver Metastasis From Renal Cell Carcinoma

## TL;DR

A rare case of liver metastasis from kidney cancer showed a unique pattern with a spared region, highlighting the importance of liver biopsy for accurate diagnosis.

## Contribution

The report presents a rare case of diffuse liver metastasis from renal cell carcinoma with a focally spared region, emphasizing the role of biopsy in diagnosis.

## Key findings

- A 27-year-old woman presented with diffuse liver metastasis from renal cell carcinoma.
- A focally spared region was identified in the metastatic liver tissue via needle biopsy.
- Liver fibrosis was absent in the biopsy specimen, distinguishing this case from typical infiltrative metastases.

## Abstract

Liver metastasis is not uncommon in various malignant tumors. Most of liver metastases present as discrete masses. However, liver metastases can appear as diffuse infiltrating neoplasms. Infiltration of malignant cells can provoke hepatic fibrosis, which mimics cirrhosis. Progress of diffuse type of liver metastasis remains unclear because of its difficulty in diagnosis or aggressive nature. In this report, we describe a 27-year-old woman with diffuse type of liver metastasis from renal cell carcinoma. The present case showed atypical findings of clinical images on liver examinations, which was histologically diagnosed as a focally spared region in diffuse type of liver metastasis by needle biopsy. Liver fibrosis was not observed in the biopsy specimen. Our case report suggests that liver biopsy is essential for diagnosis of diffuse type of liver metastasis, and the spared region can be observed in the metastatic process of the diffuse type.