# Fasting before contrast-enhanced CT and the incidence of acute adverse reactions: a single-center randomized clinical trial

## TL;DR

This study finds that fasting before contrast-enhanced CT scans does not prevent adverse reactions and may even reduce nausea and vomiting.

## Contribution

The study challenges the traditional fasting policy before contrast-enhanced CT scans by showing it is unnecessary in most cases.

## Key findings

- Unrestricted food intake before contrast-enhanced CT did not increase acute adverse reactions.
- Fasting was found to be an independent risk factor for nausea and vomiting.
- The incidence of emetic adverse reactions was significantly lower in the non-fasting group.

## Abstract

To evaluate the effect of eliminating the traditional preparatory fasting policy before contrast-enhanced CT on acute adverse reactions and to identify potential risk factors in a Spanish population sample, since many European patients still experience this unnecessary measure in clinical practice.

Outpatients who underwent non-emergency CT to either 6 h of solid food fasting (control group) or an unrestricted consumption of solids (intervention group). Adverse reactions during contrast media administration and up to 30 min afterward were recorded and their incidence was calculated. Using univariate and multivariate logistic regression analyses, various patient-related and technical factors were evaluated to identify risk factors for nausea and vomiting.

One thousand one hundred three patients were evaluated, 560 patients in the control group, and 543 patients in the intervention group. Moderate and severe acute adverse reactions were not identified in either group. No statistical difference was found in the overall acute adverse reactions (hypersensitivity and chemotoxicity) incidence between groups (3.21% vs 2.30% p = 0.36). The total incidence of emetic adverse reactions (nausea and vomiting) was significantly lower in the intervention group than in the control group (0.92% vs 2.86% p = 0.02). Multivariate logistic regression analysis revealed that fasting, age, allergies, neurological diseases, and contrast media concentration were independent risk factors for nausea and vomiting.

Unrestricted food intake did not increase the overall incidence of acute adverse reactions and diminished the incidence of nausea and vomiting.

ANZCTR, ACTRN12623000071628. Registered 23 January 2023—retrospectively registered, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=384985&showOriginal=true&isReview=true.

This randomized clinical trial carried out in adults undergoing a non-emergent CT scan demonstrates that fasting as a preparation before a contrast-enhanced CT scan should be discontinued and reserved only for certain specific imaging tests.

Despite low osmolar CT contrast media becoming ubiquitous, preparatory fasting is still widely practiced.The overall incidence of acute adverse reactions was unchanged after abolishing preparative fasting.Traditional preparatory fasting should be discontinued and reserved only for certain specific imaging tests.

Despite low osmolar CT contrast media becoming ubiquitous, preparatory fasting is still widely practiced.

The overall incidence of acute adverse reactions was unchanged after abolishing preparative fasting.

Traditional preparatory fasting should be discontinued and reserved only for certain specific imaging tests.