# Utilization of RESOLV with polymer to produce prazosin hydrochloride nanoparticles and optimization of the process parameters

## TL;DR

This study uses a new method to create small drug particles of prazosin hydrochloride, improving their size and properties for pharmaceutical use.

## Contribution

The RESOLV method is applied for the first time to produce prazosin hydrochloride nanoparticles.

## Key findings

- Particle size was reduced from 40 μm to 252–418 nm using RESOLV.
- Processed PRH showed lower crystallinity compared to original PRH.

## Abstract

In this study, rapid expansion of a supercritical solution into a Liquid Solvent (RESOLV) was used for the first time to produce pharmaceutical nanoparticles of Prazosin hydrochloride (PRH). The Taguchi method (robust design) was utilized to design the experiments and ensure obtaining the optimal process conditions. The pressure (15–25 MPa), temperature (308–328 K) and nozzle diameter (300–700 μm) effects on the morphology and size distribution of the resulting particles were also examined. The size of the particles decreased from about 40 μm to the range of (252–418 nm). FTIR, DLS, FESEM, XRD, DSC were used to characterize the primary and processed PRH particles. According to DSC investigations, RESOLV-produced PRH showed lower crystallinity than original PRH.