# RETRACTION: Microrna‐379 Suppresses Osteosarcoma Progression by Targeting PDK1

## TL;DR

This retracted paper claimed that microRNA-379 suppresses osteosarcoma by targeting PDK1, but image duplications led to its retraction.

## Contribution

The paper originally proposed a novel mechanism of microRNA-379 in suppressing osteosarcoma progression via PDK1.

## Key findings

- MicroRNA-379 was reported to inhibit osteosarcoma progression by targeting PDK1.
- Image duplication issues in figures led to the retraction of the study.
- The co-author J. Shen denied involvement in the research and its publication.

## Abstract

RETRACTION: Li, Z., Shen, J., Chan, M. T. V., and Wu, W. K. K. (2017). Microrna‐379 Suppresses Osteosarcoma Progression by Targeting PDK1. Journal of Cellular and Molecular Medicine, 21(2), 315–323. https://doi.org/10.1111/jcmm.12966

The above article, published online on 25 October 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Stefan Constantinescu; The Foundation for Cellular and Molecular Medicine and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate duplications of image panels (Figures 2D, 3, 4G, 6A and F) within the article and between this and other articles that were previously published or published shortly after in a different scientific context. The authors were unable to provide a satisfactory explanation and the provided raw data could not explain the identified issues, which has led the editors to lose confidence in the data presented. Therefore, the editors consider the conclusions substantially compromised and are retracting the paper. The co‐author, J. Shen stated that they were not involved in this research and had no knowledge about its publication, and their correspondence email address was added without their consent. The authors, including Z. Li who submitted the manuscript, were informed of the decision to retract but did not respond to the retraction or the retraction wording.