# Suspected Diphtheria Toxoid and Tetanus Toxoid (dTdap) Booster Vaccine-Induced Postural Orthostatic Tachycardia Syndrome (POTS)

## TL;DR

A woman developed POTS after a dTdap booster vaccine and improved with specific treatment, suggesting a possible link.

## Contribution

This case highlights POTS as a potential adverse event following dTdap booster vaccination.

## Key findings

- A 40-year-old woman developed POTS symptoms one week after a dTdap booster.
- Treatment with fludrocortisone and ivabradine improved the patient's condition.
- Clinicians should consider POTS as a possible vaccine adverse event after dTdap.

## Abstract

We describe a case of a 40-year-old South Asian woman who presented with symptoms suggestive of postural orthostatic tachycardia syndrome (POTS) following a diphtheria toxoid and tetanus toxoid (dTdap) booster vaccination administered one week prior. The patient’s POTS responded favorably to treatment with low-dose fludrocortisone and ivabradine. Clinicians should maintain a high index of suspicion for POTS as a possible vaccine adverse event (VAE) post-dTdap booster inoculation and be aware of appropriate management strategies.