Oxidative fluorination with Selectfluor: A convenient procedure for preparing hypervalent iodine(V) fluorides

TL;DR

A new, efficient method for making hypervalent iodine(V) fluorides using Selectfluor is introduced, offering a milder alternative to traditional harsh reagents.

Contribution

A mild and efficient procedure using Selectfluor to synthesize hypervalent iodine(V) fluorides with high yields.

Findings

Hypervalent iodine(V) fluorides were prepared in good yields (72–90%) using Selectfluor.

Bicyclic difluoro(aryl)-λ5-iodane 6 showed greater stability in acetonitrile-d3 compared to chloroform-d1.

Abstract

The ability to investigate hypervalent iodine(V) fluorides has been limited primarily by their difficult preparation traditionally using harsh fluorinating reagents such as trifluoromethyl hypofluorite and bromine trifluoride. Here, we report a mild and efficient route using Selectfluor to deliver hypervalent iodine(V) fluorides in good isolated yields (72–90%). Stability studies revealed that bicyclic difluoro(aryl)-λ5-iodane 6 was much more stable in acetonitrile-d3 than in chloroform-d1, presumably due to acetonitrile coordinating to the iodine(V) centre and stabilising it via halogen bonding.

Figures

Examples of fluorination using hypervalent iodine(III) reagents 1 and 2.

Preparations and reactions of hypervalent iodine(V) fluorides.

Bicyclic difluoro(aryl)-λ5-iodanes.

Attempted oxidative fluorination of hypervalent iodine(III) amides.

Synthesis of methyl(trifluoromethyl)fluoroiodane 15.

Synthesis of bis(trifluoromethyl)fluoroiodane 19.

Reaction of phenylmagnesium bromide with bis(trifluoromethyl)trifluoroiodane 22.

Molecular structure of difluoroiodane 6 showing 50% displacement ellipsoids.

Stability of difluoroiodane 6 in air in dry CD3CN (blue line), dry CDCl3 with 2.4 equivalents of dry pyridine (green line), and dry CDCl3 (red line).

Order of hydrolytic stability for the four hypervalent iodine(V) fluorides.

Tables

Table 1. Oxidative fluorination of iodine(I) substrate 8.

Entry	Reaction conditions	Time (h)	Yielda
			6 (%)	9 (%)
1	TCCA (4 equiv), KF (6 equiv)	48	90	10
2	TCCA (4 equiv), KF (6 equiv)	24	complex mixture
3	TCCA (3 equiv), KF (6 equiv)	48	90	10
4	TCCA (3 equiv), KF (6 equiv), work-up under N2	48	99	1
5	Selectfluor (4 equiv), work-up under N2	48	85 (56)	15

Table 2. Oxidative fluorination with Selectfluora.

Entry	Selectfluor (equiv)	Temp. (°C)	Time (h)	Conversion (%)	Yieldb
					6 (%)	9 (%)
1	5.1	40	48	100	93 (91)	7
2	2.5	40	24	100	98 (80)	2
3	2.5	25	24	97	98 (58)	2
4	2.5	40	6	99	95 (55)	5
5	1.5	40	24	99	96 (90)	4

Table 3. Oxidative fluorination of monocyclic fluoroiodanes.

Entry	R/R’	Product	Selectfluor (equiv)	Temp. (°C)	Time (h)	Yielda (%)
1	CH3/CH3	20	2.5	40	24	75
2	CH3/CF3	21	3.0	60	48	78
3	CF3/CF3	22	3.0	80	72	72

Table 4. Selected average bond lengths (Å) and average bond angles (°) with estimated standard deviations (e.s.d.s.) in parenthesis for difluoroiodane 6, trifluoroiodane 20 and fluoroiodane 2.

Average bond lengths (Å) and bond angles (°)	6	20	2
C–I	2.031(6)	2.072(7)	2.089(5)
I–F	1.975(4)	1.963(4)	–
I–F’	–	1.979(4)	2.053(3)
I–O	1.986(4)	1.924(5)	2.029(3)
F’/O–I–O	161.4(2)	167.9(2)	166.7(2)
F–I–F	172.9(2)	168.5(2)	–
C–I–F	86.7(2)	85.8(3)	–
C–I–F’	–	85.8(3)	86.8(2)
C–I–O	80.7(2)	82.5(2)	80.4(2)

Table 5. Comparing properties of hypervalent iodine(V) fluorides with hypervalent iodine(III) fluorides 2 and 19a.

	d(C–I)(Å)	d(I–F)(Å)	d(I–F’)(Å)	d(I-O/N)(Å)	qC	qI	qF	qF‘	qO/N	θF–I–F(°)	θO-I-O/F’/θN-I-N (°)
6	2.04	2.00b	–	2.03	−0.355	1.689	−0.460	–	−0.561	173.6	161.1
7a	2.06	2.00	–	2.12	−0.312	1.668	−0.426	–	−0.609	175.9	156.6
7b	2.05	1.99b	–	2.12	−0.314	1.667	−0.444	–	−0.591	176.7	156.9
20	2.09	1.98b	1.99	1.99	−0.419	1.738	−0.453	−0.449	−0.556	171.8	168.8
21	2.09	1.98c	1.98	2.01	−0.415	1.753	−0.445d	−0.439	−0.550	171.7	168.6
22	2.10	1.97b	1.97	2.03	−0.407	1.766	−0.438	−0.428	−0.540	171.4	168.5
2	2.10	–	2.04	2.07	−0.403	0.957	–	−0.490	−0.574	–	167.9
19	2.10	–	2.02	2.09	−0.387	1.009	–	−0.469	−0.552	–	167.8

Full text

Introduction

An important strategy in the drug discovery process is the incorporation of fluorine into biologically active molecules because fluorine can improve bioactivity and pharmacokinetic properties [1]. Consequently, 22% of all small-molecule drugs contain at least one fluorine atom [2]. Hypervalent iodine(III) fluorides, such as difluoroiodotoluene 1 and fluoroiodane 2, have been key to the development of numerous, new synthetic procedures for C–F bond formation over the last decade. Since difluoroiodotoluene 1 has low chemical stability and is highly hygroscopic, it is often prepared in situ and Gilmour [3–8] has reported a range of fluorination protocols utilising hypervalent iodine(I/III) catalysis (Scheme 1A). Lennox has also demonstrated that 1 can be generated cleanly by electrochemical oxidation [9–10]. In an alternative approach, we reported the first application of using fluoroiodane 2 as a fluorinating reagent in 2013 [11]. The chelate sidearm makes 2 an air-stable, easy-to-handle solid with excellent fluorinating ability and it often exhibits different reactivity to that observed with fluoroaza reagents such as Selectfluor (Scheme 1B) [12–20].

Examples of fluorination using hypervalent iodine(III) reagents 1 and 2.

In contrast to the chemistry of hypervalent iodine(III) reagents, very little is known about hypervalent iodine(V) fluorides. One problem that has blocked research into these compounds has been the lack of synthetic procedures to access them easily because they normally require harsh fluorinating reagents. The synthesis of hypervalent iodine(V) fluoride 3 was reported by Amey and Martin in 1979 using the highly toxic gas, trifluoromethyl hypofluorite (Scheme 2A), and they later prepared bicyclic hypervalent iodine(V) fluoride 4 using bromine trifluoride (Scheme 2B) [21–22]. They also showed that hypervalent iodine(V) fluoride 3 fluorinated phenylmagnesium bromide in Freon-113 to form fluorobenzene in 90% yield (Scheme 2A) and so, it is very surprising that this reagent has not been investigated further. Since then, Gruber [23] reacted a perfluorinated iodine(III) compound with XeF_2_ and postulated the formation of a (perfluoroalkyl)iodine(V) difluoride intermediate which underwent a reductive elimination to afford perfluorinated products (Scheme 2C). In 2019 Togni reported a safer route to a range of acyclic iodine(V) fluorides such as 5 (Scheme 2D) using large excesses of trichloroisocyanuric acid (TCCA) and potassium fluoride [24]. The iodine(V) fluorides were formed in good spectroscopic yields (79–94%), but only one product, tetrafluoro(4-fluorophenyl)-λ^5^-iodane 5, was isolated from the reaction mixture by performing multiple extractions into hexane under a nitrogen atmosphere in a glovebox. A similar synthetic approach to acyclic iodine(V) fluorides was developed more recently by Ismalaj and co-workers by reacting iodoarenes with 6 equivalents of KF and ex situ-generated chlorine gas within a two-chamber reactor setup, but again the iodine(V) fluorides were not isolated [25].

Preparations and reactions of hypervalent iodine(V) fluorides.

We became interested in developing a convenient procedure to access these intriguing reagents and to investigate their ability to fluorinate aryl Grignard reagents. In this paper, we report a straightforward route to hypervalent iodine(V) fluorides by reacting iodine(III) precursors with commercially available Selectfluor. The method avoids large excesses of reagents and pure iodine(V) fluorides are isolated after a simple work-up.

Results and Discussion

Preparation of bicyclic difluoro(aryl)-λ5-iodanes

Two different types of bicyclic difluoro(aryl)-λ^5^-iodanes were designed originally because of the stabilisation afforded from two five-membered rings (Figure 1). We started our investigation with bicyclic difluoro(aryl)-λ^5^-iodane 6, building on the hypervalent iodine core skeleton used in fluoroiodane 2, with an additional 5-membered ring to stabilise the iodine(V) centre. Both sidearms were also changed to amides because the NR group is a point of diversity which could be used to modulate the sterics and electronics of these novel hypervalent iodine(V) compounds.

Bicyclic difluoro(aryl)-λ5-iodanes.

Initially, we applied Togni’s oxidative fluorination protocol to iodine(I) precursor 8 (Table 1). Reacting 8 with 4 equivalents of trichloroisocyanuric acid (TCCA) and 6 equivalents of potassium fluoride in dry acetonitrile at 40 °C for 48 hours formed difluoroiodane 6 in a 90% spectroscopic yield (Table 1, entry 1). An iodosyl decomposition product 9 was also formed during the work-up procedure in air. When the reaction time was shortened to 24 hours, a complex reaction mixture was obtained (Table 1, entry 2). Reducing the amount of TCCA to 3 equivalents (Table 1, entry 3) delivered difluoroiodane 6 in the same 90% yield. Finally, we performed the reaction and work-up under inert conditions and an excellent 99% yield of difluoroiodane 6 was achieved. The main issue with this procedure, however, was that we could not extract the pure difluoroiodane 6 into hexane and separate it from the large excesses of TCCA. Selectfluor was therefore explored as an oxidative fluorinating reagent (Table 1, entry 5). When 8 was reacted with 4 equivalents of freeze-dried Selectfluor in dry acetonitrile at 40 °C for 48 hours, difluoroiodane 6 was formed in 85% spectroscopic yield. However, the iodosyl decomposition product 9 was also produced in 15% spectroscopic yield, despite working the reaction up under inert conditions.

Consequently, we decided to investigate the oxidative fluorination of iodine(III) substrate 10 with Selectfluor (Table 2). We were delighted that difluoroiodane 6 was formed in 93% spectroscopic yield and the iodosyl byproduct 9 was formed in a much lower 7% spectroscopic yield, when 10 was reacted with a large excess of Selectfluor (5.1 equivalents) in dry acetonitrile at 40 °C for 48 hours (Table 2, entry 1). More importantly, difluoroiodane 6 was isolated successfully in an excellent 91% yield by a simple extraction into dry dichloromethane providing an efficient separation from the excess Selectfluor and its byproduct. Reducing the amount of Selectfluor to 2.5 equivalents and the reaction time to 24 hours (Table 2, entry 2) resulted in a similar high yield of difluoroiodane 6. The reaction also proceeded well at either room temperature for 24 hours (Table 2, entry 3) or at 40 °C for 6 hours (Table 2, entry 4). Finally, reducing the amount of Selectfluor to 1.5 equivalents led to an excellent 90% isolated yield and the conclusion that Selectfluor delivered one electrophilic fluorine (from the N–F) and one nucleophilic fluoride (from the tetrafluoroborate, BF_4_^−^) to form difluoroiodane 6.

The formation of difluoroiodane 6 was identified by a singlet at −23.0 ppm in the ^19^F NMR spectrum. As expected, the aromatic signals in the ^1^H NMR spectrum shifted downfield from a doublet at 7.21 ppm and a triplet at 7.56 ppm for iodine(III) substrate 10 to 7.71 ppm and 7.96 ppm, respectively, for iodine(V) product 6. Similarly, the ^13^C NMR spectrum showed a major downfield shift for the aromatic carbon attached to iodine from a chemical shift of 105.3 ppm in iodine(III) substrate 10 to 132.4 ppm for difluoroiodane(V) product 6.

Since Selectfluor was shown to be the best reagent for preparing bicyclic iodine(V) difluoride 6, this route was first investigated for the oxidative fluorinations of hypervalent iodine(III) amides 11a and 11b (Scheme 3). Unfortunately, these reactions did not work and difluoro(aryl)-λ^5^-iodanes 7a and 7b were not produced. Togni’s protocol using TCCA (4 equivalents) and KF (6 equivalents) was then applied to both bicyclic iodine(III) amides 11a and 11b, but these reactions also failed to form either difluoroiodane 7a or 7b.

Attempted oxidative fluorination of hypervalent iodine(III) amides.

Following the successful preparation and isolation of difluoroiodane 6, we investigated its ability to fluorinate PhMgBr as reported with iodine(V) fluoride 3 by Amey and Martin [21]. Difluoroiodane 6 was first reacted with phenylmagnesium chloride in dry toluene at 0 °C, but fluorobenzene was not formed under these reaction conditions. The reaction was then repeated using phenylmagnesium bromide, but disappointingly, no fluorination was observed. The disparity in reactivity between difluoroiodane 6 and trifluoroiodane 3 towards aryl Grignard reagents could be attributed to the different relationships between the fluorine ligands on the iodine(V) centre. In difluoroiodane 6 the fluorine ligands are restricted to a trans-configuration because of the bicyclic carbon skeleton. Trifluoroiodane 3, on the other hand, has both trans- and cis-configurations of the fluorine ligands which could play a key role in the reductive elimination step in the fluorination of phenylmagnesium bromide. Trifluoroiodane 3 also contains two trifluoromethyl groups in the sidearm which could alter the electronic effects significantly. We therefore decided to prepare a small series of monocyclic trifluoro(aryl)-λ^5^-iodanes, where the sidearm substituents were changed stepwise from methyl to trifluoromethyl groups, so that we also formed an analogue of Amey and Martin’s monocyclic trifluoroiodane 3.

Preparation of monocyclic trifluoro(aryl)-λ5-iodanes

Our investigation into the synthesis of monocyclic trifluoro(aryl)-λ^5^-iodanes began with the preparation of the key iodine(III) precursors for our oxidative fluorination protocol. Fluoroiodane 2 was already available in our laboratory [11] and the three-step synthesis of methyl(trifluoromethyl)fluoroiodane 15 is shown in Scheme 4. The first step was a diazotisation of 2’-aminoacetophenone 12 to form 2’-iodoacetophenone 13, which was then reacted with Ruppert’s reagent (CF_3_SiMe_3_) to afford iodoalcohol 14 in 93% yield. In the final step iodoalcohol 14 underwent an oxidative fluorination with Selectfluor at room temperature to deliver methyl(trifluoromethyl)fluoroiodane 15 in a good 68% yield after recrystallisation from toluene.

Synthesis of methyl(trifluoromethyl)fluoroiodane 15.

Although bis(trifluoromethyl)fluoroiodane 19 has been reported before [26–28], we developed a new synthetic route which is shown in Scheme 5. In the first step trifluoromethylketone 17 was prepared by a nucleophilic acyl substitution of methyl 2-iodobenzoate 16 with Ruppert’s reagent. Ketone 17 was then reacted with an excess of Ruppert’s reagent and TBAF in order to form bis(trifluoromethyl)iodoalcohol 18, which was treated with Selectfluor in the final step to deliver bis(trifluoromethyl)fluoroiodane 19 in 72% yield.

Synthesis of bis(trifluoromethyl)fluoroiodane 19.

A small series of trifluoro(aryl)-λ^5^-iodanes were successfully prepared and isolated in good yields (Table 3). Dimethyltrifluoroiodane 20 was readily formed under mild reaction conditions using 2.5 equivalents of Selectfluor at 40 °C for 24 hours. However, the introduction of trifluoromethyl groups to the sidearm of the iodine(III) fluoroiodanes led to harsher oxidative fluorination conditions being required because the increased electron-withdrawing effect made the fluoroiodane precursors more resistant to oxidation. Consequently, higher temperatures, longer reaction times and more equivalents of Selectfluor were required to prepare trifluoroiodanes 21 and 22. Trifluoro(aryl)-λ^5^-iodane 22 was also prepared directly from its iodine(I) precursor 18 in 73% isolated yield in a one-pot procedure using 5.5 equivalents of Selectfluor (see Supporting Information File 1).

Unfortunately, we were never able to replicate Amey and Martin’s fluorination of phenylmagnesium bromide using bis(trifluoromethyl)trifluoroiodane 22 (Scheme 6). The major products were phenyliodane 23, presumably a result of ligand exchange and reduction, and iodoalcohol 18. Different solvents, temperatures and activators were investigated and the results are shown in Table S3 in Supporting Information File 1. Fluorobenzene was only ever observed in trace amounts (1–3 % spectroscopic yield) when BF_3_·OEt_2_ was added to the reaction mixture.

Reaction of phenylmagnesium bromide with bis(trifluoromethyl)trifluoroiodane 22.

X-ray crystallography and DFT calculations

The solid-state structure of difluoroiodane 6 is shown in Figure 2 and displays the expected square pyramidal geometry around the iodine atom, with only minor distortion (τ5 = 0.191). Since there were two unique molecules in the unit cell, Table 4 compares the average bond lengths and average bond angles of difluoroiodane 6 with trifluoroiodane 20, which was reported by Togni [24], and fluoroiodane 2 [11]. The I–F bond lengths in difluoroiodane 6 (range from 1.959(4) to 1.990(4) Å) are very similar to those in trifluoroiodane 20 (range from 1.956(4) to 1.984(4) Å), but are shorter than that in fluoroiodane 2 (2.048(3) to 2.058(3) Å) suggesting that fluorine is bound more strongly to the iodine(V) centre than in iodine(III) compounds. There is a similar contraction in the I–O bond lengths when comparing iodine(V) compounds, difluoroiodane 6 (range from 1.977(4) to 1.993(4) Å) and trifluoroiodane 20 (1.924(5) Å), with their respective iodine(III) precursors, 10 (2.096(2) Å) [29] and fluoroiodane 2 (2.029(3) Å). The F–I–F bond angle for difluoroiodane 6 (172.2(2)° to 173.6(2)°) deviates from 180°, but not to the same extent as seen with the aryl-IF_4_ compounds (169.9(1) to 170.4(1)°) or with trifluoroiodane 20 (167.9(2)° to 169.0(2)°) [24]. On the other hand, the O–I–O bond angle for difluoroiodane 6 (161.4(2)°) is much smaller than the F’–I–O bond angles in both trifluoroiodane 20 (167.2(2)° to 168.6(2)°) and fluoroiodane 2 (166.7(2)°), presumably due to the strain caused by the two five-membered rings. Similar to trifluoroiodane 20, there are two short intermolecular I^…^F contacts of 2.942(4) Å and 2.999(4) Å in the packing diagram of difluoroiodane 6 (see Figure S1 in Supporting Information File 1).

Molecular structure of difluoroiodane 6 showing 50% displacement ellipsoids.

DFT calculations were carried out to gain further insight into the structures of iodine(V) fluorides 21 and 22 whose X-ray structures could not be obtained, and hypothetical iodine(V) amides 7a and 7b which could not be made. Comparisons were made with iodine(V) compounds 6 and 20, as well as with iodine(III) compounds 2 and 19. Geometry optimisations were performed on all the compounds using Gaussian 16 at wB97xD/cc-pvdz, with a cc-pvdz-PP basis set used for the iodine atom. The calculated bond lengths and bond angles are reported in Table 5 and are in good agreement with the solid state structures. As expected, the calculated atomic charge on iodine was much higher for the iodine(V) fluorides (1.689–1.766) than in the iodine(III) fluorides (0.957–1.009) resulting in shorter I–F and I–O bond lengths. Interestingly, there is a slightly lower charge on iodine in bicyclic iodane 6 (1.689) compared to monocyclic trifluoroiodanes 20–22 (1.738–1.766) and the ipso carbon atom is slightly less electronegative (−0.355 vs −0.414) resulting in a less polar, but slightly shorter C–I bond in difluoroiodane 6 (2.031(6) Å) compared to trifluoroiodane 20 (2.072(7) Å). As you go across the series of monocyclic trifluoroiodanes 20 to 22, the I–O bond length increases slightly due to the electron-withdrawing effect of the trifluoromethyl groups in the sidearms and consequently, the synergistic effect of the 3-centre-4-electron bond causes the I–F’ bond length to decrease slightly. The only major difference between the bicyclic and monocyclic iodine(V) fluorides is the much smaller O–I–O bond angle (161.4(2) °) in difluoroiodane 6 compared to the F’–I–O bond angle (167.9(2) ° in 20) in the monocyclic iodanes 20–22. In fact, DFT calculations predicted that hypothetical difluoroiodanes 7a and 7b containing the amide sidearms would have an even more acute N–I–N bond angle (156.6–156.9 °). Furthermore, the internal chelate NCC bond angle in 7a/b (111.7°) was calculated to be bigger than the corresponding OCC angle (108.3(5)° to 109.2(5)°) in 6 due to the sp^2^-hybridised carbon in 7a/b and an sp^3^-hybridised carbon in 6. This NCC bond angle (111.7°) would certainly increase the angle strain in 7a/b and this, combined with the acute N–I–N bond angle (156.6–156.9°) caused by these two five-membered rings, could be the reason that we could not prepare these compounds.

Stability studies of hypervalent iodine(V) fluorides in solution

The stability of hypervalent iodine(V) fluorides 6, 20, 21 and 22 was studied in dry acetonitrile-d3 by ^1^H and ^19^F NMR spectroscopy over 7 days under an argon atmosphere. All four hypervalent iodine(V) fluorides were stable for the 7-day period. When the same experiment was repeated in air, iodine(V) fluorides 6, 21 and 22 decomposed to 55–65% remaining after 7 days presumably due to the moisture in the air, whereas trifluoroiodane 20 was less stable with only 37% remaining. Difluoroiodane 6 was also stable in dry chloroform-d1 under argon over 7 days**,** but it decomposed completely to iodosyl 9 after just 48 hours in dry chloroform-d1 in air (red line in Figure 3). The difference in the stability of difluoroiodane 6 in CDCl_3_ and CD_3_CN was attributed to the ability of acetonitrile to coordinate to the iodine(V) centre. Stabilisation via halogen bonding is well-established in hypervalent iodine(III) compounds and Dutton showed that pyridine formed a weak complex with dichloroiodobenzene via halogen bonding [30–32]. We therefore added dry pyridine (2.4 equivalents) to difluoroiodane 6 in CDCl_3_ to help stabilise the iodine(V) centre and the rate of decomposition was reduced significantly (green line in Figure 3).

Stability of difluoroiodane 6 in air in dry CD3CN (blue line), dry CDCl3 with 2.4 equivalents of dry pyridine (green line), and dry CDCl3 (red line).

The hydrolysis of the four hypervalent iodine(V) fluorides was also investigated in acetonitrile-d3 by adding 5 equivalents of water. All four compounds decomposed to their corresponding iodosyl compounds and the order of stability is shown in Figure 4. Difluoroiodane 6, containing two 5-membered rings, was the most stable iodine(V) fluoride whereas monocyclic trifluoroiodane 20 was the least stable and decomposed completely within the first minute. As expected, the stability of the monocyclic trifluoroiodanes 21 and 22 was increased by the stepwise incorporation of the trifluoromethyl groups into the sidearm, but trifluoroiodane 22 was less stable than bicyclic difluoro(aryl)-λ^5^-iodane 6.

Order of hydrolytic stability for the four hypervalent iodine(V) fluorides.

Conclusion

In summary, we have developed a new strategy using Selectfluor for the convenient preparation and isolation of hypervalent iodine(V) fluorides in good yields (72–90%). Unfortunately, none of the iodine(V) fluorides reacted with phenylmagnesium bromide to form fluorobenzene and we were never able to repeat Amey and Martin’s fluorination of phenylmagnesium bromide. A solid-state structure of 6 and DFT calculations on 6 and 20–22 gave insights into the geometries of the iodine(V) fluorides compared to the iodine(III) precursors. DFT results also suggested a possible reason for not being able to make iodine(V) amides 7a and 7b. An investigation into the hydrolysis of the four hypervalent iodine(V) fluorides revealed that bicyclic difluoro(aryl)-λ^5^-iodane 6 was more stable than monocyclic trifluoro(aryl)-λ^5^-iodanes 20–22 due to the incorporation of the second 5-membered ring in the 3-centre-4-electron bond.

Experimental

Dioxoiodane 10 (0.58 g, 1.8 mmol), Selectfluor (0.97 g, 2.7 mmol) and dry acetonitrile (10 mL) were charged to a dry Schlenk flask under a nitrogen atmosphere. The flask was sealed and heated to 40 °C for 24 hours. After cooling the reaction mixture to room temperature, the solvent was removed in vacuo to afford a crude orange solid. The orange solid was extracted with dry dichloromethane (3 × 5 mL) under a nitrogen atmosphere and the dichloromethane was removed in vacuo to afford difluoroiodane 6 as a pale orange solid (0.58 g, 90%).

Supporting Information

Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the Cambridge Crystallographic Data Centre and allocated the deposition numbers CCDC: 2351949 and 2351950.

File 1Experimental procedures, characterisation data, DFT calculations and ^1^H, ^13^C and ^19^F NMR spectra and crystallographic data.