# First report of an acute case of chagas disease in the municipality of Miraflores, Guaviare, Colombia

**Authors:** José Ziadé Benítez, Diana Cedeño Díaz, Luz Alba Colorado, Laureano Mosquera Murillo, María Trinidad Orozco, Sandra Vallecilla, Julio Cesar Padilla, Mario J. Olivera, José Ziadé Benítez, Diana Cedeño Díaz, Luz Alba Colorado, Laureano Mosquera Murillo, María Trinidad Orozco, Sandra Vallecilla, Julio Cesar Padilla, Mario J. Olivera

PMC · DOI: 10.17843/rpmesp.2024.412.13271 · Revista Peruana de Medicina Experimental y Salud Publica · 2024-06-13

## TL;DR

This paper reports the first case of acute Chagas disease in a 40-year-old man from Miraflores, Colombia, and outlines the diagnostic and public health responses.

## Contribution

This is the first documented case of acute Chagas disease in the municipality of Miraflores, Guaviare, Colombia.

## Key findings

- A 40-year-old man was diagnosed with acute Chagas disease after presenting with fever, headache, and other symptoms.
- Five additional cases with similar symptoms were identified, but parasitological tests were negative.
- Health education and community surveillance measures were implemented to prevent disease spread.

## Abstract

We present a case of acute phase Chagas disease in a 40-year-old male patient from Vereda Buenos Aires, Municipality of Miraflores, Department of Guaviare. The patient attended the emergency department with fever, headache, asthenia, adynamia and dysuria. The blood smear and urinalysis were positive for symptomatic urinary tract infection, but negative for malaria. Five days later the diagnosis of acute phase Chagas disease was confirmed after a positive result for Trypanosoma cruzi. The patient was treated with nifurtimox and benznidazole, his contacts and risk areas were investigated, an active entomological community and institutional search was carried out, as well as in the reservoirs, finally, laboratory surveillance for possible cases of infection in the community was conducted. Five cases with similar symptoms were identified, but parasitological tests were negative. Health education measures were implemented to prevent the spread of the disease.

Se presenta un caso de enfermedad de Chagas en fase aguda en un paciente masculino de 40 años, procedente de la Vereda Buenos Aires, Municipio de Miraflores, Departamento del Guaviare. El paciente acudió a urgencias con fiebre, cefalea, astenia, adinamia y disuria. Se realizó un frotis de sangre y un análisis de orina, con resultados positivos para infección urinaria sintomática, pero negativos para malaria. Cinco días más tarde se confirmó el diagnóstico de enfermedad de Chagas en fase aguda tras recibir un resultado positivo para Trypanosoma cruzi. El paciente recibió tratamiento con nifurtimox y benznidazol, y se llevó a cabo una investigación de contactos y zonas de riesgo, búsqueda activa comunitaria e institucional, entomológica y de reservorios, y una vigilancia de laboratorio para detectar posibles casos de infección en la comunidad. Se identificaron cinco casos con síntomas similares, pero las pruebas parasitológicas fueron negativas. Se aplicaron medidas de educación sanitaria para prevenir la propagación de la enfermedad.

## Linked entities

- **Chemicals:** nifurtimox (PubChem CID 6842999), benznidazole (PubChem CID 31593)
- **Diseases:** Chagas disease (MONDO:0001444), urinary tract infection (MONDO:0005247), malaria (MONDO:0005136)
- **Species:** Trypanosoma cruzi (taxon 5693)

## Full-text entities

- **Diseases:** adynamia (MESH:D020513), urinary tract infection (MESH:D014552), Chagas disease (MESH:D014355), dysuria (MESH:D053159), infection (MESH:D007239), headache (MESH:D006261), fever (MESH:D005334), asthenia (MESH:D001247), malaria (MESH:D008288)
- **Species:** Homo sapiens (human, species) [taxon 9606], Trypanosoma cruzi (species) [taxon 5693]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11300699/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC11300699/full.md

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Source: https://tomesphere.com/paper/PMC11300699