# A Solitary Peutz-Jeghers Hamartomatous Polyp in the Gastric Body: A Case Report

**Authors:** Noelia Madera, Noemí Acevedo, Carmen González-Peralta, Rafael Castro, Vismelis Mezquita-Luna

PMC · DOI: 10.7759/cureus.63943 · Cureus · 2024-07-06

## TL;DR

This case report describes a rare solitary Peutz-Jeghers polyp in the stomach of a 50-year-old woman, highlighting the importance of considering Peutz-Jeghers syndrome in differential diagnosis.

## Contribution

The novelty lies in reporting a rare solitary gastric Peutz-Jeghers polyp and emphasizing multidisciplinary management for early neoplasm detection.

## Key findings

- A solitary hamartomatous polyp was identified in the gastric body of a 50-year-old female.
- The case highlights the need for a multidisciplinary approach in diagnosing and monitoring Peutz-Jeghers syndrome.
- Regular endoscopic monitoring is recommended to detect potential neoplasms early.

## Abstract

Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant genetic condition characterized by the development of hamartoma-type intestinal polyposis and areas of skin pigmentation, among other signs. Additionally, the occurrence of solitary Peutz-Jeghers polyps is exceedingly rare. We present the case of a 50-year-old female with a medical history of hypothyroidism, chronic gastritis, and dyslipidemia, who presented with dyspeptic symptoms and occasional rectal bleeding. Endoscopic examination revealed a solitary hamartomatous polyp in the gastric body and other gastrointestinal abnormalities. The patient underwent treatment and is being monitored with regular endoscopic studies and evaluations for other potential neoplasms. This case underscores the importance of considering the syndrome as a potential differential diagnosis. It emphasizes the necessity of a multidisciplinary approach to managing and monitoring such cases, particularly the early detection of possible neoplasms.

## Linked entities

- **Diseases:** Peutz-Jeghers syndrome (MONDO:0008280), hypothyroidism (MONDO:0005420), chronic gastritis (MONDO:0005001), dyslipidemia (MONDO:0002525)

## Full-text entities

- **Diseases:** gastrointestinal abnormalities (MESH:D005767), skin pigmentation (MESH:D010859), dyspeptic symptoms (MESH:D012816), hamartomatous polyp (MESH:D011127), PJS (MESH:D010580), dyslipidemia (MESH:D050171), rectal bleeding (MESH:D012002), hamartoma-type intestinal polyposis (MESH:D044483), chronic gastritis (MESH:D005756), autosomal dominant genetic condition (MESH:D030342), neoplasms (MESH:D009369), hypothyroidism (MESH:D007037)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11300189/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC11300189/full.md

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Source: https://tomesphere.com/paper/PMC11300189