# Successful Treatment of Hepatitis B Virus Reactivation With a Combination of Entecavir and Short-Term Administration of Interferon-β Twice per Day

## TL;DR

A patient with hepatitis B virus reactivation was successfully treated with a combination of entecavir and interferon-β, showing promise for similar cases.

## Contribution

The study introduces a novel combination therapy using entecavir and short-term interferon-β for HBV reactivation.

## Key findings

- Combination therapy rapidly suppressed HBV replication during hepatitis.
- The treatment was effective and safe for HBV reactivation-related hepatitis.

## Abstract

Hepatitis B virus (HBV) reactivation-related hepatitis is likely to progress to acute liver failure, with high morbidity and mortality, even when nucleoside analogs are administered after the onset of hepatitis. We report a case of adult T-cell leukemia/lymphoma (ATLL) with the development of HBV reactivation-related hepatitis during chemotherapy and successful treatment by a combination of entecavir and short-term intravenous administration of interferon (IFN)-β 3 MIU twice per day. This outcome suggests that this combination therapy has a potent effect in rapidly suppressing HBV replication in the early phase of hepatitis and may be effective and safe for the treatment of HBV reactivation-related hepatitis.