# The Use of Steroids to Treat Hypercalcemia Due to Granulomatous Disease From Disseminated Coccidioidomycosis

**Authors:** Tim Yu, Stephen Bruce, Diep Nguyen, Anika Patel, Mark MacElwee

PMC · DOI: 10.7759/cureus.63977 · Cureus · 2024-07-06

## TL;DR

This paper presents a case where steroids helped treat high blood calcium caused by a fungal infection called coccidioidomycosis.

## Contribution

The paper contributes a novel case study on treating hypercalcemia in disseminated coccidioidomycosis using a combination of therapies including steroids.

## Key findings

- Hypercalcemia in disseminated coccidioidomycosis can be effectively treated with calcitonin, bisphosphonates, and corticosteroids.
- The patient showed a favorable outcome following combinatorial treatment despite controlled infection.

## Abstract

The clinical course and treatment of hypercalcemia from a granulomatous disease in the setting of an infectious etiology, namely disseminated coccidioidomycosis, remains incompletely understood. The mechanism and treatment of hypercalcemia have been documented in most granulomatous disorders, with sarcoidosis being the most well-understood so far. We discuss a case of a patient with a recent diagnosis of disseminated coccidioidomycosis who presented with hypercalcemia despite adequate infection control. The treatment course involved combinatorial-calcitonin, low-dose bisphosphonates, and corticosteroids, which led to a favorable outcome.

## Linked entities

- **Diseases:** hypercalcemia (MONDO:0001566)

## Full-text entities

- **Diseases:** Coccidioidomycosis (MESH:D003047), Hypercalcemia (MESH:D006934), infection (MESH:D007239), Granulomatous Disease (MESH:D006105), sarcoidosis (MESH:D012507)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11299706/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC11299706/full.md

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Source: https://tomesphere.com/paper/PMC11299706